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MT1B metallothionein 1B [ Homo sapiens (human) ]

Gene ID: 4490, updated on 2-Mar-2021

Summary

Official Symbol
MT1Bprovided by HGNC
Official Full Name
metallothionein 1Bprovided by HGNC
Primary source
HGNC:HGNC:7394
See related
Ensembl:ENSG00000169688 MIM:156349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1; MTP; MT1Q; MT-1B; MT-IB
Summary
The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]
Expression
Biased expression in liver (RPKM 1.6), duodenum (RPKM 0.4) and 1 other tissue See more
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Genomic context

See MT1B in Genome Data Viewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (56651886..56653204)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56685798..56687116)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene metallothionein 1D, pseudogene Neighboring gene metallothionein 1C, pseudogene Neighboring gene metallothionein 1F Neighboring gene uncharacterized LOC101927536

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of a quantitative disordered gambling trait.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
metallothionein-1B
Names
metallothionein 1B (functional)
metallothionein 1Q
metallothionein-IB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005947.3NP_005938.1  metallothionein-1B

    See identical proteins and their annotated locations for NP_005938.1

    Status: REVIEWED

    Source sequence(s)
    AC026461, AY168638
    Consensus CDS
    CCDS10765.1
    UniProtKB/Swiss-Prot
    P07438
    Related
    ENSP00000334998.2, ENST00000334346.3
    Conserved Domains (1) summary
    pfam00131
    Location:161
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    56651886..56653204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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