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Fbxl7 F-box and leucine-rich repeat protein 7 [ Mus musculus (house mouse) ]

Gene ID: 448987, updated on 26-Sep-2022

Summary

Official Symbol
Fbxl7provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 7provided by MGI
Primary source
MGI:MGI:3052506
See related
Ensembl:ENSMUSG00000043556 AllianceGenome:MGI:3052506
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBL7; Fbl6; D230018M15Rik
Summary
Involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Located in centrosome. Part of SCF ubiquitin ligase complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 5.8), ovary adult (RPKM 5.0) and 23 other tissues See more
Orthologs
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Genomic context

See Fbxl7 in Genome Data Viewer
Location:
15; 15 B1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (26540540..26895650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (26540454..26895564, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 11 Neighboring gene predicted gene, 36790 Neighboring gene predicted gene, 52206 Neighboring gene predicted gene, 52205 Neighboring gene gem-associated protein 4-like Neighboring gene ecdysoneless homolog pseudogene Neighboring gene predicted gene, 18093 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23903

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102204

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176959.3NP_795933.2  F-box/LRR-repeat protein 7

    See identical proteins and their annotated locations for NP_795933.2

    Status: PROVISIONAL

    Source sequence(s)
    BC091646
    Consensus CDS
    CCDS37052.1
    UniProtKB/Swiss-Prot
    Q5BJ29, Q6ZQ36
    UniProtKB/TrEMBL
    A0A8C6HQ73
    Related
    ENSMUSP00000061305.10, ENSMUST00000059204.11
    Conserved Domains (3) summary
    cd09293
    Location:297464
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:240273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:114160
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    26540540..26895650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520106.5XP_006520169.1  F-box/LRR-repeat protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006520169.1

    UniProtKB/TrEMBL
    A0A8C6HRT2
    Conserved Domains (3) summary
    cd09293
    Location:250417
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:193226
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:67110
    F-box-like