U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Znhit3 zinc finger, HIT type 3 [ Mus musculus (house mouse) ]

Gene ID: 448850, updated on 26-Sep-2022

Summary

Official Symbol
Znhit3provided by MGI
Official Full Name
zinc finger, HIT type 3provided by MGI
Primary source
MGI:MGI:3051596
See related
Ensembl:ENSMUSG00000020526 AllianceGenome:MGI:3051596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trip3; Myohd1; TRIP-3
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Predicted to be located in cytoplasm. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Is expressed in liver; pancreas; submandibular gland primordium; thymus primordium; and vibrissa. Human ortholog(s) of this gene implicated in PEHO syndrome. Orthologous to human ZNHIT3 (zinc finger HIT-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.4), colon adult (RPKM 15.3) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Znhit3 in Genome Data Viewer
Location:
11; 11 C
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84801776..84807192, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84910950..84916366, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene gametogenetin binding protein 2 Neighboring gene gametogenetin binding protein 2, opposite strand Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene myosin XIX Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917 Neighboring gene carbonic anhydrase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Homology

Clone Names

  • MGC107312

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snoRNA localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of pre-snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger HIT domain-containing protein 3
Names
TR-interacting protein 3
myosin head domain containing 1
thyroid hormone receptor interactor 3
thyroid receptor-interacting protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005223.3NP_001005223.1  zinc finger HIT domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001005223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (1).
    Source sequence(s)
    AI851492, AK004259, AK014350
    Consensus CDS
    CCDS25189.1
    UniProtKB/Swiss-Prot
    Q9CQK1
    UniProtKB/TrEMBL
    A0A8C6GXM5
    Related
    ENSMUSP00000099484.5, ENSMUST00000103195.5
    Conserved Domains (1) summary
    pfam04438
    Location:736
    zf-HIT; HIT zinc finger
  2. NM_001359182.1NP_001346111.1  zinc finger HIT domain-containing protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI851492, AK014350, BC089554
    UniProtKB/TrEMBL
    Q5FW88

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84801776..84807192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)