CCL28 C-C motif chemokine ligand 28 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CCL28provided by VGNC
Official Full Name: C-C motif chemokine ligand 28provided by VGNC
Primary source: VGNC:VGNC:38890
See related: RGD:12156366
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (67059634..67089860)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (66327898..66358117)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (67484045..67514790)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (66817571..66848315)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (66947140..66977927)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inflammatory cytokines are important inducing factors for the production of CCL28 in the lesional skin of dogs with atopic dermatitis. atopic dermatitis.
Title: Augmentation of CCL17 and CCL28 gene expression by TNF-alpha, IL-1beta, or IFN-gamma in cultured canine keratinocytes.
It was found that mRNA expression levels of CCL27 and CCL28 among the chemokines were significantly different between lesional and non-lesional skin in dogs with atopic dermatitis.
Title: Expression analysis of CCL27 and CCL28 mRNA in lesional and non-lesional skin of dogs with atopic dermatitis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: C-C motif chemokine 28

Names: CC chemokine ligand 28; small-inducible cytokine A28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005257.1 → NP_001005257.1 C-C motif chemokine 28 precursor

See identical proteins and their annotated locations for NP_001005257.1

Status: PROVISIONAL

Source sequence(s)

AB164619

UniProtKB/Swiss-Prot

Q68A91

UniProtKB/TrEMBL

A0A8C0R5X9, A0A8I3MJG7

Conserved Domains (1) summary

cl00134
Location:30 → 88

Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...