blmh bleomycin hydrolase [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: blmhprovided by Xenbase
Official Full Name: bleomycin hydrolaseprovided by Xenbase
Primary source: Xenbase:XB-GENE-997246
See related: Ensembl:ENSXETG00000021342 AllianceGenome:Xenbase:XB-GENE-997246
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: bh; bmh
Summary: Predicted to enable aminopeptidase activity and cysteine-type peptidase activity. Predicted to be involved in homocysteine catabolic process and response to toxic substance. Predicted to act upstream of or within proteolysis. Predicted to be active in cytoplasm. Orthologous to human BLMH (bleomycin hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	2	NC_030678.2 (32459999..32504427, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	2	NC_030678.1 (24126987..24172244)

Chromosome 2 - NC_030678.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-homocysteine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bleomycin hydrolase

NP_001006900.1

EC 3.4.22.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006899.1 → NP_001006900.1 bleomycin hydrolase

See identical proteins and their annotated locations for NP_001006900.1

Status: PROVISIONAL

Source sequence(s)

BC074683

UniProtKB/TrEMBL

A0A8J0PEB8, Q6GL32

Related

ENSXETP00000082790.1, ENSXETT00000067021.2

Conserved Domains (1) summary

cd00585
Location:5 → 450

Peptidase_C1B; Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is ...