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MST1 macrophage stimulating 1 [ Homo sapiens (human) ]

Gene ID: 4485, updated on 8-Dec-2018

Summary

Official Symbol
MST1provided by HGNC
Official Full Name
macrophage stimulating 1provided by HGNC
Primary source
HGNC:HGNC:7380
See related
Ensembl:ENSG00000173531 MIM:142408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSP; HGFL; NF15S2; D3F15S2; DNF15S2
Summary
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
Annotation information
Note: MST1 (Gene ID: 4485) and STK4 (Gene ID: 6789) share the MST1 symbol/alias in common. MST1 is a widely used alternative name for serine/threonine kinase 4 (STK4), which can be confused with the official symbol for macrophage stimulating 1 (MST1). [01 Jun 2018]
Expression
Biased expression in liver (RPKM 45.2), duodenum (RPKM 24.6) and 13 other tissues See more
Orthologs

Genomic context

See MST1 in Genome Data Viewer
Location:
3p21.31
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (49683947..49689523, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49721380..49726196, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene bassoon presynaptic cytomatrix protein Neighboring gene acylaminoacyl-peptide hydrolase Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene GDP-mannose pyrophosphorylase B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
NHGRI GWA Catalog
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
NHGRI GWA Catalog
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
NHGRI GWA Catalog
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
NHGRI GWA Catalog
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
hepatocyte growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mammary gland epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hepatocyte growth factor-like protein
Names
hepatocyte growth factor-like protein homolog
macrophage stimulating 1 (hepatocyte growth factor-like)
macrophage-stimulating protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016454.1 RefSeqGene

    Range
    5001..9817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020998.3NP_066278.3  hepatocyte growth factor-like protein precursor

    See identical proteins and their annotated locations for NP_066278.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AK222893, BM672747, DC315638, L11924
    Consensus CDS
    CCDS33757.2
    UniProtKB/Swiss-Prot
    P26927
    UniProtKB/TrEMBL
    G3XAK1, Q53GN8
    Related
    ENSP00000414287.2, ENST00000449682.2
    Conserved Domains (5) summary
    smart00020
    Location:497718
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:382464
    KR; Kringle domain
    cd00190
    Location:498721
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00024
    Location:39117
    PAN_1; PAN domain
    pfam00051
    Location:297375
    Kringle; Kringle domain

RNA

  1. NR_146060.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has several difference in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC099668

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    49683947..49689523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713166.2XP_006713229.1  hepatocyte growth factor-like protein isoform X5

    Conserved Domains (4) summary
    smart00020
    Location:452673
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:338419
    KR; Kringle domain
    cd00190
    Location:453676
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00024
    Location:39117
    PAN_1; PAN domain
  2. XM_017006461.2XP_016861950.1  hepatocyte growth factor-like protein isoform X3

  3. XM_017006463.2XP_016861952.1  hepatocyte growth factor-like protein isoform X6

  4. XM_017006460.2XP_016861949.1  hepatocyte growth factor-like protein isoform X2

  5. XM_011533732.2XP_011532034.1  hepatocyte growth factor-like protein isoform X1

    Conserved Domains (5) summary
    smart00020
    Location:527730
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:122202
    KR; Kringle domain
    cd00190
    Location:527733
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cd01099
    Location:37118
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    cl00100
    Location:202241
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
  6. XM_017006464.2XP_016861953.1  hepatocyte growth factor-like protein isoform X7

  7. XM_017006462.2XP_016861951.1  hepatocyte growth factor-like protein isoform X4

  8. XM_017006465.2XP_016861954.1  hepatocyte growth factor-like protein isoform X8

  9. XM_017006467.2XP_016861956.1  hepatocyte growth factor-like protein isoform X10

  10. XM_017006466.2XP_016861955.1  hepatocyte growth factor-like protein isoform X9

  11. XM_011533738.3XP_011532040.1  hepatocyte growth factor-like protein isoform X11

    Conserved Domains (3) summary
    smart00130
    Location:382464
    KR; Kringle domain
    pfam00024
    Location:39117
    PAN_1; PAN domain
    pfam00051
    Location:297375
    Kringle; Kringle domain
  12. XM_017006468.2XP_016861957.1  hepatocyte growth factor-like protein isoform X12

RNA

  1. XR_001740152.2 RNA Sequence

  2. XR_427273.2 RNA Sequence

  3. XR_001740150.2 RNA Sequence

  4. XR_001740149.2 RNA Sequence

  5. XR_001740151.2 RNA Sequence

  6. XR_001740153.2 RNA Sequence

  7. XR_002959536.1 RNA Sequence

  8. XR_940427.2 RNA Sequence

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