U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

plu plutonium [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44848, updated on 5-Jul-2025
Official Symbol
pluprovided by FlyBase
Official Full Name
plutoniumprovided by FlyBase
Primary source
FLYBASE:FBgn0003114
Locus tag
Dmel_CG9183
See related
AllianceGenome:FB:FBgn0003114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9183; Dmel\CG9183; Plu; PLU
Summary
Involved in egg activation and negative regulation of DNA replication. Part of serine/threonine protein kinase complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See plu in Genome Data Viewer
Location:
56F11-56F11; 2-90 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20262958..20263684, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16150463..16151189, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Hormone-sensitive lipase Neighboring gene Proliferating cell nuclear antigen Neighboring gene antisense RNA:CR43812 Neighboring gene Ribosomal protein S18 Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization. Shamanski FL, et al. Cell, 1991 Sep 20. PMID 1913810
  2. Rapid DNA Synthesis During Early Drosophila Embryogenesis Is Sensitive to Maternal Humpty Dumpty Protein Function. Lesly S, et al. Genetics, 2017 Nov. PMID 28942426, Free PMC Article
  3. Premature translation of the Drosophila zygotic genome activator Zelda is not sufficient to precociously activate gene expression. Larson ED, et al. G3 (Bethesda), 2022 Aug 25. PMID 35876878, Free PMC Article
  4. The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. Axton JM, et al. EMBO J, 1994 Jan 15. PMID 8313891, Free PMC Article
  5. Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases. Romanowski P, et al. Trends Cell Biol, 1996 May. PMID 15157470

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. component of novel protein kinase complex that specifically regulates S-M cell cycles
    Title: The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in egg activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of serine/threonine protein kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
plutonium
Names
CG9183-PA
plu-PA

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20262958..20263684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057335.3 → NP_476683.1  plutonium

    See identical proteins and their annotated locations for NP_476683.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42570, Q9V910
    UniProtKB/TrEMBL
    Q868J0
    Related
    FBpp0085618
    Conserved Domains (3) summary
    cd00204
    Location:32 → 124
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:40 → 93
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:39 → 70
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42570.1 P42570
Q868J0 Q868J0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools