hspb8 heat shock protein family B (small) member 8 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: hspb8provided by Xenbase
Official Full Name: heat shock protein family B (small) member 8provided by Xenbase
Primary source: Xenbase:XB-GENE-945643
See related: Ensembl:ENSXETG00000025255 AllianceGenome:Xenbase:XB-GENE-945643
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: h11; hmn2; cmt2l; dhmn2; e2ig1; hmn2a; hsp22
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to unfolded protein. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L; autosomal dominant distal hereditary motor neuronopathy 2; and myofibrillar myopathy 13 with rimmed vacuoles. Orthologous to human HSPB8 (heat shock protein family B (small) member 8). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (165807672..165832182)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (157221293..157245803)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein folding chaperone complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein beta-8

Names: heat shock 22kDa protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005658.1 → NP_001005658.1 heat shock protein beta-8

See identical proteins and their annotated locations for NP_001005658.1

Status: PROVISIONAL

Source sequence(s)

BC074681

UniProtKB/TrEMBL

A0ACM8Q4F5, F7CD02, Q6GL34

Related

ENSXETP00000054022.2, ENSXETT00000054022.4

Conserved Domains (1) summary

cl00175
Location:86 → 175

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.