lyn LYN proto-oncogene, Src family tyrosine kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lynprovided by ZNC
Official Full Name: LYN proto-oncogene, Src family tyrosine kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-7
See related: Ensembl:ENSDARG00000067916 AllianceGenome:ZFIN:ZDB-GENE-040912-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92124; CH73-38P6.3
Summary: Predicted to enable RNA cap trimethylguanosine synthase activity. Acts upstream of or within neutrophil chemotaxis; regulation of neutrophil chemotaxis; and response to wounding. Predicted to be active in nucleus. Is expressed in neuromast; post-vent region; and pronephric duct. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	2	NC_133177.1 (30917844..30949551, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (27577470..27609189, complement)

Chromosome 2 - NC_133177.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn oxidation or indirectly by modulating cxcl8 gene expression
Title: Duox1-derived H2O2 modulates Cxcl8 expression and neutrophil recruitment via JNK/c-JUN/AP-1 signaling and chromatin modifications.
identify the Src family kinase (SFK) Lyn as a redox sensor that mediates initial neutrophil recruitment to wounds in zebrafish larvae
Title: Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA cap trimethylguanosine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 7-methylguanosine cap hypermethylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within 7-methylguanosine cap hypermethylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RNA methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase Lyn

Names: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

NP_001004543.1

EC 2.7.10.2

XP_005163456.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004543.1 → NP_001004543.1 tyrosine-protein kinase Lyn

See identical proteins and their annotated locations for NP_001004543.1

Status: PROVISIONAL

Source sequence(s)

BC081601

UniProtKB/TrEMBL

A0A8M1N268, Q66I04

Related

ENSDARP00000040554.5, ENSDART00000040555.6

Conserved Domains (4) summary

cd10364
Location:123 → 223

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

cd12004
Location:65 → 120

SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase

cd05072
Location:237 → 508

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

pfam07714
Location:245 → 495

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133177.1 Reference GRCz12tu Primary Assembly

Range

30917844..30949551 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163399.6 → XP_005163456.1 tyrosine-protein kinase Lyn isoform X1

UniProtKB/TrEMBL

A0A8M2BAN0

Conserved Domains (4) summary

cd10364
Location:105 → 205

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

cd12004
Location:47 → 102

SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase

cd05072
Location:219 → 490

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

pfam07714
Location:227 → 477

Pkinase_Tyr; Protein tyrosine kinase