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MSMB microseminoprotein beta [ Homo sapiens (human) ]

Gene ID: 4477, updated on 15-Apr-2019

Summary

Official Symbol
MSMBprovided by HGNC
Official Full Name
microseminoprotein betaprovided by HGNC
Primary source
HGNC:HGNC:7372
See related
Ensembl:ENSG00000263639 MIM:157145
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94
Summary
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward prostate (RPKM 2642.5) See more
Orthologs

Genomic context

See MSMB in Genome Data Viewer
Location:
10q11.22
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (46033305..46046269, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51549553..51562517)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene Sharpr-MPRA regulatory region 10440 Neighboring gene nuclear receptor coactivator 4 Neighboring gene uncharacterized LOC105378287 Neighboring gene ribosomal protein L23a pseudogene 61 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 7, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Prostate cancer, hereditary, 13
MedGen: C2677821 OMIM: 611928 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic correction of PSA values using sequence variants associated with PSA levels.
NHGRI GWA Catalog
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
NHGRI GWA Catalog
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
NHGRI GWA Catalog
Genome-wide association scan for variants associated with early-onset prostate cancer.
NHGRI GWA Catalog
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
NHGRI GWA Catalog
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
NHGRI GWA Catalog
Genome-wide association study identifies genetic determinants of urine PCA3 levels in men.
NHGRI GWA Catalog
Genome-wide association study identifies new prostate cancer susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Multiple loci identified in a genome-wide association study of prostate cancer.
NHGRI GWA Catalog
Multiple newly identified loci associated with prostate cancer susceptibility.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NCOA4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
extracellular space TAS
Traceable Author Statement
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
beta-microseminoprotein
Names
immunoglobulin binding factor
prostate secreted seminal plasma protein
prostate secretory protein of 94 amino acids
seminal plasma beta-inhibin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011551.1 RefSeqGene

    Range
    5001..17965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002443.4NP_002434.1  beta-microseminoprotein isoform a precursor

    See identical proteins and their annotated locations for NP_002434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PSP94) encodes the full length isoform (a).
    Source sequence(s)
    BC005257, BM856408
    Consensus CDS
    CCDS73096.1
    UniProtKB/Swiss-Prot
    P08118
    Related
    ENSP00000463092.1, ENST00000582163.3
    Conserved Domains (1) summary
    pfam05825
    Location:21114
    PSP94; Beta-microseminoprotein (PSP-94)
  2. NM_138634.2NP_619540.1  beta-microseminoprotein isoform b precursor

    See identical proteins and their annotated locations for NP_619540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PSP57) lacks an alternate coding exon compared to variant PSP94, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BF680662, BM856408
    Consensus CDS
    CCDS73095.1
    UniProtKB/Swiss-Prot
    P08118
    Related
    ENSP00000462641.1, ENST00000581478.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    46033305..46046269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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