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MSMB microseminoprotein beta [ Homo sapiens (human) ]

Gene ID: 4477, updated on 23-Nov-2021

Summary

Official Symbol
MSMBprovided by HGNC
Official Full Name
microseminoprotein betaprovided by HGNC
Primary source
HGNC:HGNC:7372
See related
Ensembl:ENSG00000263639 MIM:157145
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94
Summary
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward prostate (RPKM 2642.5) See more
Orthologs
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Genomic context

See MSMB in Genome Data Viewer
Location:
10q11.22
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (46033313..46046269, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51549553..51562509)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene Sharpr-MPRA regulatory region 10440 Neighboring gene nuclear receptor coactivator 4 Neighboring gene Sharpr-MPRA regulatory region 5969 Neighboring gene uncharacterized LOC105378287 Neighboring gene Sharpr-MPRA regulatory region 2638 Neighboring gene ribosomal protein L23a pseudogene 61

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic correction of PSA values using sequence variants associated with PSA levels.
GeneReviews: Not available
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
GeneReviews: Not available
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
GeneReviews: Not available
Genome-wide association scan for variants associated with early-onset prostate cancer.
GeneReviews: Not available
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
GeneReviews: Not available
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
GeneReviews: Not available
Genome-wide association study identifies genetic determinants of urine PCA3 levels in men.
GeneReviews: Not available
Genome-wide association study identifies new prostate cancer susceptibility loci.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Multiple loci identified in a genome-wide association study of prostate cancer.
GeneReviews: Not available
Multiple newly identified loci associated with prostate cancer susceptibility.
GeneReviews: Not available
Prostate cancer, hereditary, 13
MedGen: C2677821 OMIM: 611928 GeneReviews: Not available
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Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NCOA4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
beta-microseminoprotein
Names
immunoglobulin binding factor
prostate secreted seminal plasma protein
prostate secretory protein of 94 amino acids
seminal plasma beta-inhibin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011551.1 RefSeqGene

    Range
    5001..17957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002443.4NP_002434.1  beta-microseminoprotein isoform a precursor

    See identical proteins and their annotated locations for NP_002434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PSP94) encodes the full length isoform (a).
    Source sequence(s)
    BC005257, BM856408
    Consensus CDS
    CCDS73096.1
    UniProtKB/Swiss-Prot
    P08118
    Related
    ENSP00000463092.1, ENST00000582163.3
    Conserved Domains (1) summary
    pfam05825
    Location:21114
    PSP94; Beta-microseminoprotein (PSP-94)
  2. NM_138634.3NP_619540.1  beta-microseminoprotein isoform b precursor

    See identical proteins and their annotated locations for NP_619540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PSP57) lacks an alternate coding exon compared to variant PSP94, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BF680662
    Consensus CDS
    CCDS73095.1
    UniProtKB/Swiss-Prot
    P08118
    Related
    ENSP00000462641.1, ENST00000581478.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    46033313..46046269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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