prpf4.L pre-mRNA splicing tri-snRNP complex factor PRPF4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: prpf4.L
Official Full Name: pre-mRNA splicing tri-snRNP complex factor PRPF4 L homeolog
Primary source: Xenbase:XB-GENE-6077684
Locus tag: XELAEV_18038191mg
See related: EnsemblRapid:ENSXLAG00005019006 AllianceGenome:Xenbase:XB-GENE-6077684
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: prpf4
Summary: Predicted to be located in nuclear speck. Predicted to be part of spliceosomal complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

Location:: chromosome: 8L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (1685556..1692828, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (1512964..1520177, complement)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pre-mRNA processing factor 4 L homeolog; pre-mRNA splicing tri-snRNP complex factor PRPF4 L homeolog

Names: PRP4 pre-mRNA processing factor 4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094183.1 → NP_001087652.1 pre-mRNA splicing tri-snRNP complex factor PRPF4 L homeolog

See identical proteins and their annotated locations for NP_001087652.1

Status: PROVISIONAL

Source sequence(s)

BC081044

UniProtKB/TrEMBL

A0A974C5J2, Q66J65

Related

ENSXLAP00005056109.1, ENSXLAT00005057338.1

Conserved Domains (4) summary

smart00500
Location:87 → 125

SFM; Splicing Factor Motif, present in Prp18 and Pr04

COG2319
Location:223 → 406

WD40; WD40 repeat [General function prediction only]

cd00200
Location:217 → 405

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:219 → 255

7WD40; WD40 repeat [structural motif]