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cwo clockwork orange [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44669, updated on 28-Aug-2019

Summary

Official Symbol
cwoprovided by FlyBase
Official Full Name
clockwork orangeprovided by FlyBase
Primary source
FLYBASE:FBgn0259938
Locus tag
Dmel_CG17100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF24476.1; bHLHe49; CG17100; Cwo; CWO; dcwo; Dmel\CG17100; GM05287; mel_cwo

Genomic context

See cwo in Genome Data Viewer
Location:
86B3-86B3; 3-49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10388258..10400752)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6213980..6226474)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rfx Neighboring gene long non-coding RNA:CR44938 Neighboring gene methuselah-like 11 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
peripheral nervous system development TAS
Traceable Author Statement
more info
PubMed 
regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
clockwork orange
Names
CG17100-PA
CG17100-PB
CG17100-PC
CLOCKWORK ORANGE
clockworkorange
cwo-PA
cwo-PB
cwo-PC
stich

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10388258..10400752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260096.2NP_001247025.1  clockwork orange, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247025.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRI9
    Related
    FBpp0293682, FBtr0305152
    Conserved Domains (2) summary
    smart00511
    Location:4991
    ORANGE; Orange domain
    pfam00010
    Location:141
    HLH; Helix-loop-helix DNA-binding domain
  2. NM_080036.3NP_524775.1  clockwork orange, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VGZ5
    Related
    FBpp0081723, FBtr0082246
    Conserved Domains (2) summary
    smart00511
    Location:126168
    ORANGE; Orange domain
    pfam00010
    Location:66118
    HLH; Helix-loop-helix DNA-binding domain
  3. NM_001260095.2NP_001247024.1  clockwork orange, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247024.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRI9
    Related
    FBpp0293681, FBtr0305151
    Conserved Domains (2) summary
    smart00511
    Location:4991
    ORANGE; Orange domain
    pfam00010
    Location:141
    HLH; Helix-loop-helix DNA-binding domain
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