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Apc APC-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44642, updated on 26-Aug-2021

Summary

Official Symbol
Apcprovided by FlyBase
Official Full Name
APC-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0015589
Locus tag
Dmel_CG1451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
apc; APC; apc 1; apc1; Apc1; APC1; CG1451; d-APC; D-APC; D-APC1; dApc; dAPC; DAPC; dapc1; dAPC1; Dm APC1; Dmel\CG1451
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Genomic context

See Apc in Genome Data Viewer
Location:
98E5-98E6; 3-97 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28832301..28844748, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24658023..24670470, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene WASp Neighboring gene sponge Neighboring gene Innexin 3 Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 17

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chitin-based larval cuticle pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of compound eye retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in oocyte localization involved in germarium-derived egg chamber formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ovarian follicle cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of axo-dendritic protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in segment polarity determination IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
part_of beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of beta-catenin destruction complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
APC-like
Names
Apc-PA
Apc-PB
Apc-PC
CG1451-PA
CG1451-PB
CG1451-PC
adenomatous polyposis coli
adenomatous polyposis coli 1
adenomatous polyposis coli protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    28832301..28844748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057804.3NP_477152.1  APC-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477152.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAS9
    Related
    FBpp0084720, FBtr0085351
    Conserved Domains (3) summary
    cd00020
    Location:506624
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:903927
    APC_crr; APC cysteine-rich region
    sd00043
    Location:498539
    ARM; armadillo repeat [structural motif]
  2. NM_001316494.1NP_001303423.1  APC-like, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GV30
    Related
    FBpp0401491, FBtr0445314
    Conserved Domains (4) summary
    cd00020
    Location:506624
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:903927
    APC_crr; APC cysteine-rich region
    pfam16629
    Location:648694
    Arm_APC_u3; Armadillo-associated region on APC
    sd00043
    Location:498539
    ARM; armadillo repeat [structural motif]
  3. NM_001276117.1NP_001263046.1  APC-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263046.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAS9
    Related
    FBpp0307743, FBtr0336767
    Conserved Domains (3) summary
    cd00020
    Location:506624
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:903927
    APC_crr; APC cysteine-rich region
    sd00043
    Location:498539
    ARM; armadillo repeat [structural motif]
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