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ZNG1C Zn regulated GTPase metalloprotein activator 1C [ Homo sapiens (human) ]

Gene ID: 445571, updated on 5-Aug-2026
Official Symbol
ZNG1Cprovided by HGNC
Official Full Name
Zn regulated GTPase metalloprotein activator 1Cprovided by HGNC
Primary source
HGNC:HGNC:18519
See related
Ensembl:ENSG00000196873 MIM:611080; AllianceGenome:HGNC:18519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBWD3; bA561O23.1
Summary
Predicted to enable GTP binding activity; hydrolase activity; and metal ion binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in small intestine (RPKM 6.1), thyroid (RPKM 5.9) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ZNG1C in Genome Data Viewer
Location:
9q21.11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (68241983..68300035)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (80416505..80473721)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (70856899..70914951)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928608 Neighboring gene ankyrin repeat domain 20 family member A1 Neighboring gene RNA, U6 small nuclear 368, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:70837488-70837989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:70895397-70895980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:70895981-70896564 Neighboring gene uncharacterized LOC124902173 Neighboring gene uncharacterized LOC107987077 Neighboring gene forkhead box D4 like 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. Fan Y, et al. Genome Res, 2002 Nov. PMID 12421752, Free PMC Article
  2. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Weiss A, et al. Cell, 2022 Jun 9. PMID 35584702, Free PMC Article
  3. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Nishiyama M, et al. Stem Cells, 2015 Nov. PMID 26124079
  4. Diverse fates of paralogs following segmental duplication of telomeric genes. Wong A, et al. Genomics, 2004 Aug. PMID 15233989
  5. A conserved acetylation switch enables pharmacological control of tubby-like protein stability. Kerek EM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33187986, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ60409

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc chaperone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
zinc-regulated GTPase metalloprotein activator 1C
Names
COBW domain containing 3
cobalamin synthase W domain-containing protein 3
cobalamin synthetase W domain-containing protein 3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291821.2 → NP_001278750.1  zinc-regulated GTPase metalloprotein activator 1C isoform 2

    See identical proteins and their annotated locations for NP_001278750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (2).
    Source sequence(s)
    AL353608
    UniProtKB/TrEMBL
    A0A0A6YYH9, A0ACI8Q2X4
    Related
    ENSP00000560655.1, ENST00000890596.2
    Conserved Domains (3) summary
    COG0523
    Location:42 → 356
    YejR; GTPase, G3E family [General function prediction only]
    pfam02492
    Location:43 → 211
    cobW; CobW/HypB/UreG, nucleotide-binding domain
    pfam07683
    Location:254 → 353
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain

  2. NM_001378113.1 → NP_001365042.1  zinc-regulated GTPase metalloprotein activator 1C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    UniProtKB/TrEMBL
    A0ACI8TXP9, A0ACI8TYG4
    Related
    ENSP00000607693.1, ENST00000937634.2
    Conserved Domains (3) summary
    COG3044
    Location:19 → 62
    COG3044; Predicted ATPase of the ABC class [General function prediction only]
    cd03112
    Location:43 → 246
    CobW-like; cobalamin synthesis protein CobW
    pfam07683
    Location:290 → 350
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain

  3. NM_001378114.1 → NP_001365043.1  zinc-regulated GTPase metalloprotein activator 1C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    UniProtKB/TrEMBL
    A0ACI8RLX4, A0ACI8TZA3
    Related
    ENSP00000560659.1, ENST00000890600.2
    Conserved Domains (2) summary
    COG0523
    Location:42 → 347
    YejR; GTPase, G3E family [General function prediction only]
    COG3044
    Location:19 → 62
    COG3044; Predicted ATPase of the ABC class [General function prediction only]

  4. NM_001378115.1 → NP_001365044.1  zinc-regulated GTPase metalloprotein activator 1C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    UniProtKB/TrEMBL
    A0ACI8TXU7
    Conserved Domains (2) summary
    cd03112
    Location:43 → 217
    CobW-like; cobalamin synthesis protein CobW
    pfam07683
    Location:245 → 344
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain

  5. NM_001378116.1 → NP_001365045.1  zinc-regulated GTPase metalloprotein activator 1C isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (6).
    Source sequence(s)
    AL353608
    UniProtKB/TrEMBL
    A0ACI8RPB8, A0ACI8UZ64
    Related
    ENSP00000560657.1, ENST00000890598.2
    Conserved Domains (2) summary
    COG0523
    Location:42 → 327
    YejR; GTPase, G3E family [General function prediction only]
    COG3044
    Location:19 → 62
    COG3044; Predicted ATPase of the ABC class [General function prediction only]

  6. NM_001378117.1 → NP_001365046.1  zinc-regulated GTPase metalloprotein activator 1C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    UniProtKB/TrEMBL
    A0ACI8TXP7
    Conserved Domains (3) summary
    COG3044
    Location:19 → 62
    COG3044; Predicted ATPase of the ABC class [General function prediction only]
    cd03112
    Location:43 → 206
    CobW-like; cobalamin synthesis protein CobW
    pfam07683
    Location:242 → 302
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain

  7. NM_201453.4 → NP_958861.2  zinc-regulated GTPase metalloprotein activator 1C isoform 1

    See identical proteins and their annotated locations for NP_958861.2

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    Consensus CDS
    CCDS35038.2
    UniProtKB/Swiss-Prot
    B4DNG9, Q5JTY5, Q6VB91
    UniProtKB/TrEMBL
    A0ACI8TXU7
    Related
    ENSP00000353295.6, ENST00000360171.11
    Conserved Domains (3) summary
    COG0523
    Location:42 → 376
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:274 → 373
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43 → 207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_178045.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, non-coding) uses the same exon combination as variant (2, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068269

  2. NR_178046.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6, non-coding) uses the same exon combination as variant (6, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068269

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    68241983..68300035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    80416505..80473721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JTY5.1 GenPept UniProtKB/Swiss-Prot:Q5JTY5

Gene LinkOut

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