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CBWD3 COBW domain containing 3 [ Homo sapiens (human) ]

Gene ID: 445571, updated on 5-Jan-2022

Summary

Official Symbol
CBWD3provided by HGNC
Official Full Name
COBW domain containing 3provided by HGNC
Primary source
HGNC:HGNC:18519
See related
Ensembl:ENSG00000196873 MIM:611080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA561O23.1
Summary
Predicted to enable ATP binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in small intestine (RPKM 6.1), thyroid (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

See CBWD3 in Genome Data Viewer
Location:
9q21.11
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (68241866..68300035)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (70856899..70914951)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 20 family member A1 Neighboring gene RNA, U6 small nuclear 368, pseudogene Neighboring gene ankyrin repeat domain 18A pseudogene Neighboring gene uncharacterized LOC107987077 Neighboring gene forkhead box D4 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ60409

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
COBW domain-containing protein 3
Names
cobalamin synthase W domain-containing protein 3
cobalamin synthetase W domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291821.2NP_001278750.1  COBW domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001278750.1

    Status: VALIDATED

    Source sequence(s)
    AL353608
    UniProtKB/Swiss-Prot
    Q5JTY5
    UniProtKB/TrEMBL
    A0A0A6YYH9
    Conserved Domains (3) summary
    COG0523
    Location:42356
    YejR; GTPase, G3E family [General function prediction only]
    pfam02492
    Location:43211
    cobW; CobW/HypB/UreG, nucleotide-binding domain
    pfam07683
    Location:254353
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  2. NM_001378113.1NP_001365042.1  COBW domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    Conserved Domains (3) summary
    COG3044
    Location:1962
    COG3044; Predicted ATPase of the ABC class [General function prediction only]
    cd03112
    Location:43246
    CobW-like; cobalamin synthesis protein CobW
    pfam07683
    Location:290350
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  3. NM_001378114.1NP_001365043.1  COBW domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    Conserved Domains (2) summary
    COG0523
    Location:42347
    YejR; GTPase, G3E family [General function prediction only]
    COG3044
    Location:1962
    COG3044; Predicted ATPase of the ABC class [General function prediction only]
  4. NM_001378115.1NP_001365044.1  COBW domain-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    Conserved Domains (2) summary
    cd03112
    Location:43217
    CobW-like; cobalamin synthesis protein CobW
    pfam07683
    Location:245344
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  5. NM_001378116.1NP_001365045.1  COBW domain-containing protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL353608
    Conserved Domains (2) summary
    COG0523
    Location:42327
    YejR; GTPase, G3E family [General function prediction only]
    COG3044
    Location:1962
    COG3044; Predicted ATPase of the ABC class [General function prediction only]
  6. NM_001378117.1NP_001365046.1  COBW domain-containing protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    Conserved Domains (3) summary
    COG3044
    Location:1962
    COG3044; Predicted ATPase of the ABC class [General function prediction only]
    cd03112
    Location:43206
    CobW-like; cobalamin synthesis protein CobW
    pfam07683
    Location:242302
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  7. NM_201453.4NP_958861.2  COBW domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_958861.2

    Status: VALIDATED

    Source sequence(s)
    AL353608, FQ976557
    Consensus CDS
    CCDS35038.2
    UniProtKB/Swiss-Prot
    Q5JTY5
    Related
    ENSP00000353295.6, ENST00000360171.11
    Conserved Domains (3) summary
    COG0523
    Location:42376
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:274373
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    68241866..68300035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717116.1XP_006717179.1  COBW domain-containing protein 3 isoform X5

    Conserved Domains (2) summary
    COG0523
    Location:42317
    YejR; GTPase, G3E family [General function prediction only]
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005277637.2XP_005277694.1  COBW domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MRU4
    Related
    ENSP00000366559.6, ENST00000377342.9
    Conserved Domains (3) summary
    COG0523
    Location:42357
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:255354
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005277640.2XP_005277697.1  COBW domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A087WWG3
    Related
    ENSP00000480203.1, ENST00000618217.4
    Conserved Domains (3) summary
    COG0523
    Location:42328
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:226325
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011518706.2XP_011517008.1  COBW domain-containing protein 3 isoform X6

    See identical proteins and their annotated locations for XP_011517008.1

    Conserved Domains (2) summary
    pfam07683
    Location:106205
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:2063
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_017014732.1XP_016870221.1  COBW domain-containing protein 3 isoform X7

RNA

  1. XR_001746300.1 RNA Sequence

  2. XR_001746299.1 RNA Sequence

    Related
    ENST00000615061.4
  3. XR_002956784.1 RNA Sequence

  4. XR_001746297.1 RNA Sequence

  5. XR_001746303.1 RNA Sequence

  6. XR_001746302.1 RNA Sequence

  7. XR_001746301.1 RNA Sequence

  8. XR_001746304.1 RNA Sequence

  9. XR_929803.1 RNA Sequence

  10. XR_929802.1 RNA Sequence

  11. XR_001746298.1 RNA Sequence

  12. XR_929804.1 RNA Sequence

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