emp2 epithelial membrane protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: emp2provided by ZNC
Official Full Name: epithelial membrane protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040822-24
See related: Ensembl:ENSDARG00000044588 AllianceGenome:ZFIN:ZDB-GENE-040822-24
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: EMP-2; zgc:100935
Summary: Involved in regulation of glomerular filtration. Predicted to be located in Golgi apparatus; apical plasma membrane; and nucleus. Predicted to be active in plasma membrane. Is expressed in blood vessel; orbit; pectoral fin; pharyngeal arch; and pronephros. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	3	NC_133178.1 (25768181..25796646)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (27027781..27056180)

Chromosome 3 - NC_133178.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of emp2 in zebrafish resulted in pericardial effusion, supporting the pathogenic role of mutated EMP2 in human nephrotic syndrome.
Title: Mutations in EMP2 cause childhood-onset nephrotic syndrome.

Submit: New GeneRIF Correction

General gene information

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Markers

fc46g04.y1 (e-PCR)
- UniSTS:193942

fc23e05.x1 (e-PCR)
- UniSTS:187836

fb83h07.x1 (e-PCR)
- UniSTS:203503

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: epithelial membrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004119.1 → NP_001004119.1 epithelial membrane protein 2

See identical proteins and their annotated locations for NP_001004119.1

Status: PROVISIONAL

Source sequence(s)

BC080211

UniProtKB/TrEMBL

Q68EL5

Conserved Domains (1) summary

cl21598
Location:1 → 153

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family