Format

Send to:

Choose Destination

Thbs1 thrombospondin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 445442, updated on 27-Nov-2020

Summary

Symbol
Thbs1provided by RGD
Full Name
thrombospondin 1provided by RGD
Primary source
RGD:1588455
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tsp1; TSP-1
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Uterus (RPKM 700.5), Kidney (RPKM 591.6) and 5 other tissues See more
Orthologs

Genomic context

See Thbs1 in Genome Data Viewer
Location:
3q35
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (109862120..109873466)
106 current Rn_Celera (GCF_000002265.2) 3 AC_000071.1 (103978436..103990486)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (116411045..116422101)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691867 Neighboring gene uncharacterized LOC102547459 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene fibrous sheath interacting protein 1 Neighboring gene G protein-coupled receptor 176

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
collagen V binding ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix binding ISO
Inferred from Sequence Orthology
more info
 
fibrinogen binding ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
laminin binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
behavioral response to pain ISO
Inferred from Sequence Orthology
more info
 
blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
chronic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
engulfment of apoptotic cell ISO
Inferred from Sequence Orthology
more info
 
growth plate cartilage development ISO
Inferred from Sequence Orthology
more info
 
immune response ISO
Inferred from Sequence Orthology
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic cell antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
negative regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
peptide cross-linking ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
response to glucose ISO
Inferred from Sequence Orthology
more info
 
response to magnesium ion ISO
Inferred from Sequence Orthology
more info
 
response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
fibrinogen complex ISO
Inferred from Sequence Orthology
more info
 
platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
secretory granule ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013062.2NP_001013080.2  thrombospondin-1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000118

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    109862120..109873466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    103978436..103990486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center