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Hnf4 Hepatocyte nuclear factor 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44544, updated on 11-Sep-2021

Summary

Official Symbol
Hnf4provided by FlyBase
Official Full Name
Hepatocyte nuclear factor 4provided by FlyBase
Primary source
FLYBASE:FBgn0004914
Locus tag
Dmel_CG9310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9310; dHNF-4; dHNF4; Dmel\CG9310; DmHNF4; Hnf-4; HNF-4; HNF-4(D); Hnf-4h; HNF4; HNF4alpha; NHF4; NR2A4
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Genomic context

See Hnf4 in Genome Data Viewer
Location:
29E4-29E4; 2-33 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8687226..8709611, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8687226..8709611, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Prenyl-binding protein Neighboring gene TRAPP subunit 23 Neighboring gene antisense RNA:CR44992 Neighboring gene uncharacterized protein Neighboring gene raw Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hepatocyte nuclear factor 4
Names
CG9310-PA
CG9310-PB
CG9310-PD
CG9310-PE
CG9310-PF
Hnf4-PA
Hnf4-PB
Hnf4-PD
Hnf4-PE
Hnf4-PF
hepatocyte nuclear factor 4 homologue

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8687226..8709611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164834.2NP_723414.2  hepatocyte nuclear factor 4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723414.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49866
    Related
    FBpp0307616, FBtr0336633
    Conserved Domains (2) summary
    cd06931
    Location:236466
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:142217
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  2. NM_057539.5NP_476887.2  hepatocyte nuclear factor 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476887.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49866
    Related
    FBpp0079349, FBtr0079747
    Conserved Domains (2) summary
    cd06931
    Location:236466
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:142217
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  3. NM_001103656.3NP_001097126.1  hepatocyte nuclear factor 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097126.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49866
    Related
    FBpp0111759, FBtr0112846
    Conserved Domains (2) summary
    cd06931
    Location:240470
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:146221
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  4. NM_001298829.1NP_001285758.1  hepatocyte nuclear factor 4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285758.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J9X1
    Related
    FBpp0311113, FBtr0344784
    Conserved Domains (2) summary
    cd06931
    Location:198428
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:104179
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  5. NM_164833.2NP_723413.1  hepatocyte nuclear factor 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49866
    Related
    FBpp0079350, FBtr0079748
    Conserved Domains (2) summary
    cd06931
    Location:264494
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:170245
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
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