mpl MPL proto-oncogene, thrombopoietin receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mplprovided by ZNC
Official Full Name: MPL proto-oncogene, thrombopoietin receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060421-1
See related: Ensembl:ENSDARG00000039222 AllianceGenome:ZFIN:ZDB-GENE-060421-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mpll; tpor; c-mpl; tpor.b
Summary: Predicted to enable cytokine receptor activity. Acts upstream of or within thrombocyte differentiation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in blood; nucleate erythrocyte; thrombocyte; and ventral wall of dorsal aorta. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia 1; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	6	NC_133181.1 (36470111..36501556, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (33949107..33980908, complement)

Chromosome 6 - NC_133181.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thrombocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thrombopoietin receptor

Names: cytokine receptor; myeloproliferative leukemia virus oncogene, like; thrombopoietin receptor c-mpl

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003858.1 → NP_001003858.1 thrombopoietin receptor precursor

See identical proteins and their annotated locations for NP_001003858.1

Status: PROVISIONAL

Source sequence(s)

AY319287

UniProtKB/TrEMBL

A0A8M2BDQ1, Q6EIY6

Related

ENSDARP00000109739.2, ENSDART00000124917.4

Conserved Domains (2) summary

cd00063
Location:314 → 403

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09067
Location:23 → 122

EpoR_lig-bind; Erythropoietin receptor, ligand binding