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il12ba interleukin 12Ba [ Danio rerio (zebrafish) ]

Gene ID: 445373, updated on 9-Sep-2025
Official Symbol
il12baprovided by ZNC
Official Full Name
interleukin 12Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050525-3
See related
Ensembl:ENSDARG00000033727 AllianceGenome:ZFIN:ZDB-GENE-050525-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
il12b; IL-12 p40; il12p40.b; zgc:152789
Summary
Predicted to enable interleukin-12 alpha subunit binding activity and interleukin-12 receptor binding activity. Predicted to contribute to cytokine activity. Predicted to be involved in interleukin-12-mediated signaling pathway. Predicted to be located in extracellular space. Predicted to be part of interleukin-12 complex. Is expressed in brain; dendritic cell; and intestine. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See il12ba in Genome Data Viewer
Location:
chromosome: 14
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (39398096..39564335)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (34950560..34959787)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene actin binding LIM protein family, member 3 Neighboring gene SH3 domain and tetratricopeptide repeats 2 Neighboring gene adrenoceptor beta 2, surface a Neighboring gene ring finger protein 145a Neighboring gene uncharacterized LOC141377560 Neighboring gene EBF transcription factor 1a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Discovery of zebrafish (Danio rerio) interleukin-23 alpha (IL-23α) chain, a subunit important for the formation of IL-23, a cytokine involved in the development of Th17 cells and inflammation. Holt A, et al. Mol Immunol, 2011 Apr. PMID 21324528
  2. Identification of dendritic antigen-presenting cells in the zebrafish. Lugo-Villarino G, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20733076, Free PMC Article
  3. Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits. Nascimento DS, et al. Mol Immunol, 2007 Mar. PMID 17196658
  4. A high-sensitivity bi-directional reporter to monitor NF-κB activity in cell culture and zebrafish in real time. Kuri P, et al. J Cell Sci, 2017 Feb 1. PMID 27980067
  5. Systemic response to ultraviolet radiation involves induction of leukocytic IL-1β and inflammation in zebrafish. Banerjee S, et al. J Immunol, 2014 Aug 1. PMID 24965777

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC152789

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-12 alpha subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-12 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-12-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
part_of interleukin-12 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
interleukin 12Ba precursor
Names
il-12p40.a
interleukin 12 p40.b
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
interleukin-12 p40 subunit

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007108.1 → NP_001007109.1  interleukin 12Ba precursor

    See identical proteins and their annotated locations for NP_001007109.1

    Status: PROVISIONAL

    Source sequence(s)
    AB183002
    UniProtKB/TrEMBL
    A0AB32T2C1, Q6F3Q9
    Related
    ENSDARP00000047523.7, ENSDART00000047524.9
    Conserved Domains (1) summary
    pfam10420
    Location:121 → 199
    IL12p40_C; Cytokine interleukin-12p40 C-terminus

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    39398096..39564335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073921341.1 → XP_073777442.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  2. XM_073921348.1 → XP_073777449.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  3. XM_073921344.1 → XP_073777445.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  4. XM_073921345.1 → XP_073777446.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  5. XM_073921342.1 → XP_073777443.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  6. XM_073921350.1 → XP_073777451.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  7. XM_073921349.1 → XP_073777450.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  8. XM_073921351.1 → XP_073777452.1  interleukin 12Ba precursor isoform X5

    UniProtKB/TrEMBL
    A0AB32T2C1

  9. XM_073921352.1 → XP_073777453.1  interleukin 12Ba precursor isoform X5

    UniProtKB/TrEMBL
    A0AB32T2C1

  10. XM_073921343.1 → XP_073777444.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  11. XM_073921346.1 → XP_073777447.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  12. XM_073921347.1 → XP_073777448.1  interleukin 12Ba precursor isoform X4

    UniProtKB/TrEMBL
    A0AB32T2C1

  13. XM_073921338.1 → XP_073777439.1  interleukin 12Ba precursor isoform X1

    UniProtKB/TrEMBL
    A0AB32T2C1

  14. XM_073921339.1 → XP_073777440.1  interleukin 12Ba precursor isoform X2

    UniProtKB/TrEMBL
    A0AB32T2C1

  15. XM_073921340.1 → XP_073777441.1  interleukin 12Ba precursor isoform X3

    UniProtKB/TrEMBL
    A0AB32T2C1

RNA

  1. XR_012389483.1 RNA Sequence

  2. XR_011006137.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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