TARP TCR gamma alternate reading frame protein [Homo sapiens (human)] - Gene

Summary

Gene symbol: TARP
Gene description: TCR gamma alternate reading frame protein
See related: Ensembl:ENSG00000289746 MIM:609642
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD3G; TCRG; TCRGV; TCRGC1; TCRGC2
Summary: In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein. [provided by RefSeq, Jul 2008]
Expression: Biased expression in prostate (RPKM 38.4), bone marrow (RPKM 13.6) and 3 other tissues See more
Orthologs: all
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Genomic context

Location:: 7p14.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (38259643..38273636, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (38416644..38430635, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (38299244..38313237, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.
Title: High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.
The expression of TARP and KRT5 was correlated with the progress of endometrial cancer
Title: Value of T cell receptor gamma alternate reading frame protein and keratin 5 in endometrial carcinoma.
The results of this study found decreased transcript expression of TARP gamma-8 in schizophrenia.
Title: Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia.
T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.
Title: T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration.
up-regulated in prostate cancer tissue
Title: Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy.
A prognostic value of TARP in prostate cancer could not be found.
Title: Diagnostic and prognostic value of T-cell receptor gamma alternative reading frame protein (TARP) expression in prostate cancer.
Intracellular protein degradation and endosomal acidification were significantly delayed in gammadelta T-antigen-presenting cells compared with human monocyte-derived dendritic cells(moDCs).
Title: Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells.
Nine peptides and two proteins were identified for TCRgammadelta, including human mutS homolog 2 (hMSH2) and heat shock protein (HSP) 60.
Title: Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2865 (e-PCR)
- UniSTS:82071

TCRG (e-PCR), detects polymorphism
- UniSTS:9391

Homology

Homologs of the TARP gene: The TARP gene is conserved in Rhesus monkey, dog, cow, chicken, and frog.
Orthologs from Annotation Pipeline: 146 organisms have orthologs with human gene TARP
Orthologs

General protein information

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Preferred Names: TCR gamma alternate reading frame protein

Names: T cell receptor gamma chain variable; T-cell receptor gamma-chain constant region; TCR V3-JP2-Cgamma2; TCR- gamma V-IV; Vgamma9ChainTCRMOP; antigen, T-cell receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029035.1 RefSeqGene

Range

5001..19005

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GenBank, FASTA, Sequence Viewer (Graphics)
NG_001336.2

Range

100301..114305

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001003799.2 → NP_001003799.1 TCR gamma alternate reading frame protein isoform 1

See identical proteins and their annotated locations for NP_001003799.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses the upstream ORF. The resulting protein (isoform 1) localizes to the outer mitochondrial membrane.

Source sequence(s)

AF151103, BF674593

Consensus CDS

CCDS94087.1

UniProtKB/TrEMBL

A2JGV3

Related

ENSP00000513628.1, ENST00000698248.1
NM_001003806.2 → NP_001003806.1 TCR gamma alternate reading frame protein isoform 2

See identical proteins and their annotated locations for NP_001003806.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses the downstream ORF. The resulting protein (isoform 2) is similar to but shorter than TRG@ proteins, since this transcript does not include any variable regions.

Source sequence(s)

AF151103, BF674593

UniProtKB/TrEMBL

A2JGV3, Q0VGM3

Conserved Domains (1) summary

cl11960
Location:1 → 44

Ig; Immunoglobulin domain