U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TARP TCR gamma alternate reading frame protein [ Homo sapiens (human) ]

Gene ID: 445347, updated on 9-Jun-2025
Gene symbol
TARP
Gene description
TCR gamma alternate reading frame protein
See related
Ensembl:ENSG00000289746 MIM:609642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD3G
Summary
In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 38.4), bone marrow (RPKM 13.6) and 3 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See TARP in Genome Data Viewer
Location:
7p14.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (38259643..38273636, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (38416644..38430635, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (38299244..38313237, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma locus Neighboring gene T cell receptor gamma joining 2 Neighboring gene T cell receptor gamma joining P2 Neighboring gene T cell receptor gamma constant 1 Neighboring gene T cell receptor gamma joining 1 Neighboring gene T cell receptor gamma joining P Neighboring gene T cell receptor gamma joining P1 Neighboring gene T cell receptor gamma variable 11 (non-functional)

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment. Depreter B, et al. Haematologica, 2020 May. PMID 31371409, Free PMC Article
  2. Further evidence for a gamma/delta T cell receptor-mediated TCT.1/CD48 recognition. Mami-Chouaib F, et al. J Immunol, 1991 Nov 1. PMID 1655899
  3. Arrangements and rearrangements of the human T-cell receptor gamma gene. Pelicci PG, et al. Ann N Y Acad Sci, 1987. PMID 2964218
  4. Characterization of a third form of the human T cell receptor gamma/delta. Hochstenbach F, et al. J Exp Med, 1988 Aug 1. PMID 3261778, Free PMC Article
  5. Human TCR-gamma/delta alloreactive response to HLA-DR molecules. Comparison with response of TCR-alpha/beta. Flament C, et al. J Immunol, 1994 Oct 1. PMID 8089476

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.
    Title: High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.
  2. The expression of TARP and KRT5 was correlated with the progress of endometrial cancer
    Title: Value of T cell receptor gamma alternate reading frame protein and keratin 5 in endometrial carcinoma.
  3. The results of this study found decreased transcript expression of TARP gamma-8 in schizophrenia.
    Title: Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia.
  4. T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.
    Title: T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration.
  6. up-regulated in prostate cancer tissue
    Title: Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy.
  7. A prognostic value of TARP in prostate cancer could not be found.
    Title: Diagnostic and prognostic value of T-cell receptor gamma alternative reading frame protein (TARP) expression in prostate cancer.
  8. Intracellular protein degradation and endosomal acidification were significantly delayed in gammadelta T-antigen-presenting cells compared with human monocyte-derived dendritic cells(moDCs).
    Title: Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells.
  9. Nine peptides and two proteins were identified for TCRgammadelta, including human mutS homolog 2 (hMSH2) and heat shock protein (HSP) 60.
    Title: Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
T-cell receptor gamma alternate reading frame protein
Names
TCR- gamma V-IV
antigen, T-cell receptor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029035.1 RefSeqGene

    Range
    5001..19005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NG_001336.3 

    Range
    105005..118998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003799.2 → NP_001003799.1  T-cell receptor gamma alternate reading frame protein isoform 1

    See identical proteins and their annotated locations for NP_001003799.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses the upstream ORF. The resulting protein (isoform 1) localizes to the outer mitochondrial membrane.
    Source sequence(s)
    AF151103, BF674593
    Consensus CDS
    CCDS94087.1
    UniProtKB/Swiss-Prot
    A2JGV3
    Related
    ENSP00000513628.1, ENST00000698248.1

  2. NM_001003806.2 → NP_001003806.1  T-cell receptor gamma alternate reading frame protein isoform 2

    See identical proteins and their annotated locations for NP_001003806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses the downstream ORF. The resulting protein (isoform 2) is similar to but shorter than TRG@ proteins, since this transcript does not include any variable regions.
    Source sequence(s)
    AF151103, BF674593
    UniProtKB/TrEMBL
    Q0VGM3
    Conserved Domains (1) summary
    cl11960
    Location:1 → 44
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    38259643..38273636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    38416644..38430635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2JGV3.1 GenPept UniProtKB/Swiss-Prot:A2JGV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials