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TARP TCR gamma alternate reading frame protein [ Homo sapiens (human) ]

Gene ID: 445347, updated on 24-Jul-2021

Summary

Gene symbol
TARP
Gene description
TCR gamma alternate reading frame protein
Primary source
MIM:609642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD3G; TCRG; TCRGV; TCRGC1; TCRGC2
Summary
In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 38.4), bone marrow (RPKM 13.6) and 3 other tissues See more
Orthologs
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Genomic context

See TARP in Genome Data Viewer
Location:
7p14.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (38239577..38276741, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (38299244..38313237, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375236 Neighboring gene STARD3 N-terminal like Neighboring gene T cell receptor gamma constant 2 Neighboring gene uncharacterized LOC107986784 Neighboring gene T cell receptor gamma locus Neighboring gene T cell receptor gamma joining P2 Neighboring gene T cell receptor gamma joining 2 Neighboring gene T cell receptor gamma constant 1 Neighboring gene T cell receptor gamma joining 1 Neighboring gene T cell receptor gamma joining P1 Neighboring gene T cell receptor gamma joining P Neighboring gene T cell receptor gamma variable 11 (non-functional)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
TCR gamma alternate reading frame protein
Names
T cell receptor gamma chain variable
T-cell receptor gamma-chain constant region
TCR V3-JP2-Cgamma2
TCR- gamma V-IV
Vgamma9ChainTCRMOP
antigen, T-cell receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029035.1 RefSeqGene

    Range
    5001..19005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NG_001336.2 

    Range
    100301..114305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003799.2NP_001003799.1  TCR gamma alternate reading frame protein isoform 1

    See identical proteins and their annotated locations for NP_001003799.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses the upstream ORF. The resulting protein (isoform 1) localizes to the outer mitochondrial membrane.
    Source sequence(s)
    AF151103, BF674593
    UniProtKB/TrEMBL
    A2JGV3
  2. NM_001003806.2NP_001003806.1  TCR gamma alternate reading frame protein isoform 2

    See identical proteins and their annotated locations for NP_001003806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses the downstream ORF. The resulting protein (isoform 2) is similar to but shorter than TRG@ proteins, since this transcript does not include any variable regions.
    Source sequence(s)
    AF151103, BF674593
    UniProtKB/TrEMBL
    A2JGV3, Q0VGM3
    Conserved Domains (1) summary
    cl11960
    Location:144
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    38239577..38276741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012226.1XP_016867715.1  TCR gamma alternate reading frame protein isoform X1

  2. XM_017012228.1XP_016867717.1  TCR gamma alternate reading frame protein isoform X3

  3. XM_017012229.1XP_016867718.1  TCR gamma alternate reading frame protein isoform X4

    UniProtKB/TrEMBL
    A2JGV3
  4. XM_017012227.1XP_016867716.1  TCR gamma alternate reading frame protein isoform X2

    UniProtKB/TrEMBL
    Q0VGM3
    Conserved Domains (1) summary
    cl11960
    Location:144
    Ig; Immunoglobulin domain
  5. XM_011515407.2XP_011513709.1  TCR gamma alternate reading frame protein isoform X2

    See identical proteins and their annotated locations for XP_011513709.1

    UniProtKB/TrEMBL
    Q0VGM3
    Conserved Domains (1) summary
    cl11960
    Location:144
    Ig; Immunoglobulin domain
  6. XM_017012230.1XP_016867719.1  TCR gamma alternate reading frame protein isoform X4

    UniProtKB/TrEMBL
    A2JGV3
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