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TARP TCR gamma alternate reading frame protein [ Homo sapiens (human) ]

Gene ID: 445347, updated on 24-Jul-2021

Summary

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Gene symbol
TARP
Gene description
TCR gamma alternate reading frame protein
Primary source
MIM:609642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD3G; TCRG; TCRGV; TCRGC1; TCRGC2
Summary
In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 38.4), bone marrow (RPKM 13.6) and 3 other tissues See more
Orthologs
all
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Genomic context

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See TARP in Genome Data Viewer
Location:
7p14.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (38239577..38276741, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (38299244..38313237, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375236 Neighboring gene STARD3 N-terminal like Neighboring gene T cell receptor gamma constant 2 Neighboring gene uncharacterized LOC107986784 Neighboring gene T cell receptor gamma locus Neighboring gene T cell receptor gamma joining P2 Neighboring gene T cell receptor gamma joining 2 Neighboring gene T cell receptor gamma constant 1 Neighboring gene T cell receptor gamma joining 1 Neighboring gene T cell receptor gamma joining P1 Neighboring gene T cell receptor gamma joining P Neighboring gene T cell receptor gamma variable 11 (non-functional)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia. Drummond JB, et al. Schizophr Res, 2013 Jun. PMID 23566497, Free PMC Article
  2. Diagnostic and prognostic value of T-cell receptor gamma alternative reading frame protein (TARP) expression in prostate cancer. Fritzsche FR, et al. Histol Histopathol, 2010 Jun. PMID 20376779
  3. TRGV and TRDV repertoire distribution and clonality of T cells from umbilical cord blood. Li Y, et al. Transpl Immunol, 2009 Jan. PMID 19013241
  4. TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus. Wolfgang CD, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931945, Free PMC Article
  5. Preferential rearrangements of the V gamma I subgroup of the gamma-chain of the T-cell antigen receptor to J gamma 2C gamma 2 gene segments in peripheral blood lymphocyte transcripts from normal donors. Mathioudakis G, et al. Scand J Immunol, 1993 Jul. PMID 8392223

See all (32) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.
    Title: High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.
  2. The expression of TARP and KRT5 was correlated with the progress of endometrial cancer
    Title: Value of T cell receptor gamma alternate reading frame protein and keratin 5 in endometrial carcinoma.
  3. The results of this study found decreased transcript expression of TARP gamma-8 in schizophrenia.
    Title: Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia.
  4. T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.
    Title: T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration.
  6. up-regulated in prostate cancer tissue
    Title: Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy.
  7. A prognostic value of TARP in prostate cancer could not be found.
    Title: Diagnostic and prognostic value of T-cell receptor gamma alternative reading frame protein (TARP) expression in prostate cancer.
  8. Intracellular protein degradation and endosomal acidification were significantly delayed in gammadelta T-antigen-presenting cells compared with human monocyte-derived dendritic cells(moDCs).
    Title: Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells.
  9. Nine peptides and two proteins were identified for TCRgammadelta, including human mutS homolog 2 (hMSH2) and heat shock protein (HSP) 60.
    Title: Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
TCR gamma alternate reading frame protein
Names
T cell receptor gamma chain variable
T-cell receptor gamma-chain constant region
TCR V3-JP2-Cgamma2
TCR- gamma V-IV
Vgamma9ChainTCRMOP
antigen, T-cell receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029035.1 RefSeqGene

    Range
    5001..19005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NG_001336.2 

    Range
    100301..114305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003799.2 → NP_001003799.1  TCR gamma alternate reading frame protein isoform 1

    See identical proteins and their annotated locations for NP_001003799.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses the upstream ORF. The resulting protein (isoform 1) localizes to the outer mitochondrial membrane.
    Source sequence(s)
    AF151103, BF674593
    UniProtKB/TrEMBL
    A2JGV3

  2. NM_001003806.2 → NP_001003806.1  TCR gamma alternate reading frame protein isoform 2

    See identical proteins and their annotated locations for NP_001003806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses the downstream ORF. The resulting protein (isoform 2) is similar to but shorter than TRG@ proteins, since this transcript does not include any variable regions.
    Source sequence(s)
    AF151103, BF674593
    UniProtKB/TrEMBL
    A2JGV3, Q0VGM3
    Conserved Domains (1) summary
    cl11960
    Location:1 → 44
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    38239577..38276741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012226.1 → XP_016867715.1  TCR gamma alternate reading frame protein isoform X1

  2. XM_017012228.1 → XP_016867717.1  TCR gamma alternate reading frame protein isoform X3

  3. XM_017012229.1 → XP_016867718.1  TCR gamma alternate reading frame protein isoform X4

    UniProtKB/TrEMBL
    A2JGV3

  4. XM_017012227.1 → XP_016867716.1  TCR gamma alternate reading frame protein isoform X2

    UniProtKB/TrEMBL
    Q0VGM3
    Conserved Domains (1) summary
    cl11960
    Location:1 → 44
    Ig; Immunoglobulin domain

  5. XM_011515407.2 → XP_011513709.1  TCR gamma alternate reading frame protein isoform X2

    See identical proteins and their annotated locations for XP_011513709.1

    UniProtKB/TrEMBL
    Q0VGM3
    Conserved Domains (1) summary
    cl11960
    Location:1 → 44
    Ig; Immunoglobulin domain

  6. XM_017012230.1 → XP_016867719.1  TCR gamma alternate reading frame protein isoform X4

    UniProtKB/TrEMBL
    A2JGV3
Nucleotide Protein
Heading Accession and Version

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