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SULT1A4 sulfotransferase family 1A member 4 [ Homo sapiens (human) ]

Gene ID: 445329, updated on 18-Aug-2020

Summary

Official Symbol
SULT1A4provided by HGNC
Official Full Name
sulfotransferase family 1A member 4provided by HGNC
Primary source
HGNC:HGNC:30004
See related
Ensembl:ENSG00000213648 MIM:615819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STM; HAST3; M-PST; ST1A3; ST1A4; TL-PST; ST1A3/ST1A4
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Expression
Broad expression in duodenum (RPKM 135.4), small intestine (RPKM 94.3) and 23 other tissues See more
Orthologs

Genomic context

See SULT1A4 in Genome Data Viewer
Location:
16p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (29459913..29464966)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29471207..29476301)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene BOLA2-SMG1P6 readthrough Neighboring gene coronin 1A pseudogene Neighboring gene SLX1B-SULT1A4 readthrough (NMD candidate) Neighboring gene bolA family member 2 Neighboring gene SLX1 homolog B, structure-specific endonuclease subunit Neighboring gene SAGA complex associated factor 29 pseudogene Neighboring gene uncharacterized LOC101928556 Neighboring gene nuclear pore complex interacting protein family member B12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough SLX1B-SULT1A4

Readthrough gene: SLX1B-SULT1A4, Included gene: SLX1B

Homology

Clone Names

  • FLJ54864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amine sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
aryl sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
aryl sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfate binding IDA
Inferred from Direct Assay
more info
PubMed 
sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
NMDA selective glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
calcineurin-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to dopamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ethanol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
flavonoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sulfation IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfotransferase 1A4
Names
SLX1B-SULT1A4
Sulfotransferase 1A3
aryl sulfotransferase 1A3/1A4
catecholamine-sulfating phenol sulfotransferase
monoamine-sulfating phenol sulfotransferase
placental estrogen sulfotransferase
sulfokinase
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase, monoamine-preferring
thermolabile phenol sulfotransferase
NP_001017390.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017390.3NP_001017390.1  sulfotransferase 1A4

    See identical proteins and their annotated locations for NP_001017390.1

    Status: REVIEWED

    Source sequence(s)
    AC133555
    Consensus CDS
    CCDS32427.1
    UniProtKB/Swiss-Prot
    P0DMM9, P0DMN0
    UniProtKB/TrEMBL
    Q1ET61
    Related
    ENSP00000353600.7, ENST00000360423.11
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    29459913..29464966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017389.1: Suppressed sequence

    Description
    NM_001017389.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001017391.1: Suppressed sequence

    Description
    NM_001017391.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
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