U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [ Danio rerio (zebrafish) ]

Gene ID: 445289, updated on 9-Sep-2025
Official Symbol
krasprovided by ZNC
Official Full Name
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homologprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040808-67
See related
Ensembl:ENSDARG00000010844 AllianceGenome:ZFIN:ZDB-GENE-040808-67
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
K-ras; xRAS2; fa04e08; fc14b12; fc23g10; fj89d12; zgc:85725; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within embryonic cranial skeleton morphogenesis; heart development; and hemopoiesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See kras in Genome Data Viewer
Location:
chromosome: 25
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 25 NC_133200.1 (33493152..33518409, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 25 NC_007136.7 (31093653..31118912, complement)

Chromosome 25 - NC_133200.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 469 Neighboring gene microRNA 135a Neighboring gene Ras association domain family member 8a Neighboring gene cytosolic 5'-nucleotidase 1A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Amphiphilic hydroxyethyl starch-based nanoparticles carrying linoleic acid modified berberine inhibit the expression of kras(v12) oncogene in zebrafish. Yu X, et al. Biomed Pharmacother, 2024 Jul. PMID 38795642
  2. Rapid Analysis of Effects of Environmental Toxicants on Tumorigenesis and Inflammation Using a Transgenic Zebrafish Model for Liver Cancer. Yang Q, et al. Mar Biotechnol (NY), 2019 Jun. PMID 30852708
  3. Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy. Wang S, et al. ACS Nano, 2019 Mar 26. PMID 30763072
  4. Collaborative assembly of doxorubicin and galactosyl diblock glycopolymers for targeted drug delivery of hepatocellular carcinoma. Li J, et al. Biomater Sci, 2020 Jan 1. PMID 31821399
  5. Transcriptomic analyses of oncogenic hepatocytes reveal common and different molecular pathways of hepatocarcinogenesis in different developmental stages and genders in kras(G12V) transgenic zebrafish. Huo X, et al. Biochem Biophys Res Commun, 2019 Mar 19. PMID 30739784

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition.
    Title: Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition.
  2. ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma.
    Title: ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma.
  3. KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion.
    Title: KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion.
  4. Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model.
    Title: Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model.
  5. Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling.
    Title: Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling.
  6. In this study using an inducible kras transgenic zebrafish models for Hepatocellular carcinoma, transcriptomic profiles of oncogenic hepatocytes from larvae, male and female adult fish following a brief induction of oncogenic kras were investigated. Male oncogenic hepatocytes have more severe features than female counterparts.
    Title: Transcriptomic analyses of oncogenic hepatocytes reveal common and different molecular pathways of hepatocarcinogenesis in different developmental stages and genders in kras(G12V) transgenic zebrafish.
  7. the lepr mutant background had a higher survival rate and significantly lower muscle-wasting level after tumor induction than the tumor fish in the wild-type background.
    Title: Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model.
  8. the difference of liver tumorigenesis between female and male fish during early tumorigenesis and long-term tumor progression in previously established inducible and reversible HCC model - the kras(V12) transgenic zebrafish, were investigated.
    Title: Males develop faster and more severe hepatocellular carcinoma than females in kras(V12) transgenic zebrafish.
  9. Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.
    Title: Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models.
  10. Kras(V12) transgenic system offers a novel model for understanding hepatocarcinogenesis and a high-throughput screening platform for anti-cancer drugs.
    Title: An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
GTPase KRas
Names
ras-like protein
NP_001003744.1
NP_001349423.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003744.2 → NP_001003744.1  GTPase KRas isoform 2

    See identical proteins and their annotated locations for NP_001003744.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    JBMGRA010000025
    UniProtKB/TrEMBL
    F6NPA7, Q1HGL0, Q6AZA4
    Related
    ENSDARP00000021124.7, ENSDART00000009126.10
    Conserved Domains (2) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00010
    Location:16 → 166
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

  2. NM_001362494.1 → NP_001349423.1  GTPase KRas isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    JBMGRA010000025
    UniProtKB/TrEMBL
    A0A2R8Q8S1, A0A8M3AZT3
    Related
    ENSDARP00000147703.1, ENSDART00000188286.1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RNA

  1. NR_155755.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    JBMGRA010000025

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133200.1 Reference GRCz12tu Primary Assembly

    Range
    33493152..33518409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_012399849.1 RNA Sequence

  2. XR_012399848.1 RNA Sequence

  3. XR_012399850.1 RNA Sequence

  4. XR_012399847.1 RNA Sequence

  5. XR_012399844.1 RNA Sequence

  6. XR_012399846.1 RNA Sequence

  7. XR_012399842.1 RNA Sequence

  8. XR_012399845.1 RNA Sequence

  9. XR_012399843.1 RNA Sequence

  10. XR_012399841.1 RNA Sequence

  11. XR_012399840.1 RNA Sequence

  12. XR_012399835.1 RNA Sequence

  13. XR_012399839.1 RNA Sequence

  14. XR_012399834.1 RNA Sequence

  15. XR_012399838.1 RNA Sequence

  16. XR_012399836.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools