dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dpm1provided by ZNC
Official Full Name: dolichyl-phosphate mannosyltransferase subunit 1, catalyticprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-115
See related: Ensembl:ENSDARG00000057011 AllianceGenome:ZFIN:ZDB-GENE-040801-115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101018
Summary: Predicted to enable dolichyl-phosphate beta-D-mannosyltransferase activity and dolichyl-phosphate-mannose-protein mannosyltransferase activity. Acts upstream of or within muscle structure development. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in brain; cloaca; pronephric duct; solid lens vesicle; and vertical myoseptum. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	23	NC_133198.1 (23417924..23422225)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (20513128..20517429)

Chromosome 23 - NC_133198.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dolichyl-phosphate beta-D-mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-phosphate beta-D-mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl-phosphate beta-D-mannosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle structure development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation via mannose	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked glycosylation via mannose	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dolichol-phosphate mannosyltransferase subunit 1

Names: dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

NP_001003596.1

EC 2.4.1.83

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003596.1 → NP_001003596.1 dolichol-phosphate mannosyltransferase subunit 1

See identical proteins and their annotated locations for NP_001003596.1

Status: PROVISIONAL

Source sequence(s)

BC077113

UniProtKB/TrEMBL

A0A8M1N1P1, Q6DEJ9

Related

ENSDARP00000074043.2, ENSDART00000079591.3

Conserved Domains (2) summary

cd06442
Location:19 → 246

DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1

PLN02726
Location:8 → 250

PLN02726; dolichyl-phosphate beta-D-mannosyltransferase