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g6pc1a.1 glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 445118, updated on 28-Apr-2024

Summary

Official Symbol
g6pc1a.1provided by ZNC
Official Full Name
glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-031001-4
See related
Ensembl:ENSDARG00000031616 AllianceGenome:ZFIN:ZDB-GENE-031001-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
g6pc; cb822; g6pca; g6pca.1; zgc:92368
Summary
Predicted to enable glucose-6-phosphatase activity. Predicted to be involved in gluconeogenesis and glucose 6-phosphate metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in digestive system; liver; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and type 2 diabetes mellitus. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See g6pc1a.1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (6021725..6034056, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5989885..6000335, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:ch211-131k2.2 Neighboring gene K(lysine) acetyltransferase 7b Neighboring gene uncharacterized LOC110440138 Neighboring gene prostaglandin E synthase 3 like Neighboring gene glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 2 Neighboring gene alanyl-tRNA synthetase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glucose-6-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucose-6-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1
Names
glucose-6-phosphatase a, catalytic, tandem duplicate 1
glucose-6-phosphatase, catalytic
NP_001003512.2
NP_001303265.1
XP_009304709.1
XP_017213936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003512.2NP_001003512.2  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX248126, EH484431, EH520605
    UniProtKB/TrEMBL
    A0A8M1N1J9, F1Q559
    Related
    ENSDARP00000116534.1, ENSDART00000139419.3
    Conserved Domains (2) summary
    COG0671
    Location:35197
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03381
    Location:38261
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...
  2. NM_001316336.1NP_001303265.1  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    BX248126, EH484431, EH488933, EH494161, EH520605
    UniProtKB/TrEMBL
    A0A8M1P7S6, E7F5Z2
    Related
    ENSDARP00000030904.7, ENSDART00000032050.8
    Conserved Domains (1) summary
    cd03381
    Location:38231
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    6021725..6034056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358447.2XP_017213936.1  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z3H1
  2. XM_009306434.3XP_009304709.1  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform X1

    See identical proteins and their annotated locations for XP_009304709.1

    UniProtKB/TrEMBL
    A0A8M1N1J9, F1Q559
    Conserved Domains (2) summary
    COG0671
    Location:35197
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03381
    Location:38261
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...