dhrs3a dehydrogenase/reductase (SDR family) member 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhrs3aprovided by ZNC
Official Full Name: dehydrogenase/reductase (SDR family) member 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-217
See related: Ensembl:ENSDARG00000044982 AllianceGenome:ZFIN:ZDB-GENE-040801-217
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dhrs3; fc04h12; zgc:91839
Summary: Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within regulation of retinoic acid receptor signaling pathway. Predicted to be active in lipid droplet. Is expressed in several structures, including mesoderm; nervous system; optic fissure; presumptive mesoderm; and pronephric duct. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (21663742..21674679)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (21737191..21748128)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dhrs3a is thus an retinoic acid (RA)-induced feedback inhibitor of RA biosynthesis.
Title: Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: short-chain dehydrogenase/reductase 3a

Names: dehydrogenase/reductase (SDR family) member 3; retd

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003477.1 → NP_001003477.1 short-chain dehydrogenase/reductase 3a

See identical proteins and their annotated locations for NP_001003477.1

Status: PROVISIONAL

Source sequence(s)

BC078383

UniProtKB/TrEMBL

A0A2R8QGW0, F6NNM9, Q6DBS5

Related

ENSDARP00000066124.4, ENSDART00000066125.5

Conserved Domains (2) summary

cd05339
Location:53 → 281

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

PRK09072
Location:41 → 291

PRK09072; short chain dehydrogenase; Provisional