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dhrs3a dehydrogenase/reductase (SDR family) member 3a [ Danio rerio (zebrafish) ]

Gene ID: 445083, updated on 20-Feb-2026
Official Symbol
dhrs3aprovided by ZNC
Official Full Name
dehydrogenase/reductase (SDR family) member 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-217
See related
Ensembl:ENSDARG00000044982 AllianceGenome:ZFIN:ZDB-GENE-040801-217
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dhrs3; fc04h12; zgc:91839
Summary
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within regulation of retinoic acid receptor signaling pathway. Predicted to be active in lipid droplet. Is expressed in several structures, including mesoderm; nervous system; optic fissure; presumptive mesoderm; and pronephric duct. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See dhrs3a in Genome Data Viewer
Location:
chromosome: 23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 23 NC_133198.1 (24574961..24585892)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 23 NC_007134.7 (21663742..21674679)

Chromosome 23 - NC_133198.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 10-like b Neighboring gene regulator of chromosome condensation 2 Neighboring gene uncharacterized LOC141380488 Neighboring gene immunoglobin superfamily, member 21b Neighboring gene vacuolar protein sorting 13 homolog D Neighboring gene uncharacterized LOC137489120 Neighboring gene leucine rich repeat containing 38a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Triiodothyronine-induced changes in the zebrafish transcriptome during the eleutheroembryonic stage: implications for bisphenol A developmental toxicity. Pelayo S, et al. Aquat Toxicol, 2012 Apr. PMID 22281776
  2. A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish. Solanki AK, et al. Cells, 2020 Apr 29. PMID 32365517, Free PMC Article
  3. Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart. Chen J, et al. Physiol Genomics, 2008 Apr 22. PMID 18230668
  4. The Retinol Binding Protein Receptor 2 (Rbpr2) is required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish. Shi Y, et al. Sci Rep, 2017 Nov 24. PMID 29176573, Free PMC Article
  5. Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Waxman JS, et al. Dev Biol, 2011 Apr 1. PMID 21276787, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dhrs3a is thus an retinoic acid (RA)-induced feedback inhibitor of RA biosynthesis.
    Title: Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of retinoic acid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
short-chain dehydrogenase/reductase 3a
Names
dehydrogenase/reductase (SDR family) member 3
retd

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003477.1 → NP_001003477.1  short-chain dehydrogenase/reductase 3a

    See identical proteins and their annotated locations for NP_001003477.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078383
    UniProtKB/TrEMBL
    A0A2R8QGW0, F6NNM9, Q6DBS5
    Related
    ENSDARP00000066124.4, ENSDART00000066125.5
    Conserved Domains (2) summary
    cd05339
    Location:53 → 281
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    PRK09072
    Location:41 → 291
    PRK09072; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133198.1 Reference GRCz12tu Primary Assembly

    Range
    24574961..24585892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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