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IGFL4 IGF like family member 4 [ Homo sapiens (human) ]

Gene ID: 444882, updated on 13-May-2022

Summary

Official Symbol
IGFL4provided by HGNC
Official Full Name
IGF like family member 4provided by HGNC
Primary source
HGNC:HGNC:32931
See related
Ensembl:ENSG00000204869 MIM:610547; AllianceGenome:HGNC:32931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable signaling receptor binding activity. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 2.1), brain (RPKM 0.4) and 1 other tissue See more
Orthologs
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Genomic context

See IGFL4 in Genome Data Viewer
Location:
19q13.32
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46039182..46077629, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48866645..48905083, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46542440..46580887, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372421 Neighboring gene peptidoglycan recognition protein 1 Neighboring gene IGF like family member 2 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene IGF like family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ39303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
insulin growth factor-like family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002923.3NP_001002923.1  insulin growth factor-like family member 4 precursor

    See identical proteins and their annotated locations for NP_001002923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC007785
    Consensus CDS
    CCDS33057.1
    UniProtKB/Swiss-Prot
    Q6B9Z1
    Related
    ENSP00000366926.1, ENST00000377697.2
    Conserved Domains (1) summary
    pfam14653
    Location:20108
    IGFL; Insulin growth factor-like family

RNA

  1. NR_163175.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785
  2. NR_163176.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785
  3. NR_163177.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785
  4. NR_169756.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785
  5. NR_169757.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46039182..46077629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438851.1XP_047294807.1  insulin growth factor-like family member 4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48866645..48905083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_125344.1: Suppressed sequence

    Description
    NR_125344.1: This RefSeq was removed because currently there is insufficient support for the transcript.