GluRIB Glutamate receptor IB [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GluRIBprovided by FlyBase
Official Full Name: Glutamate receptor IBprovided by FlyBase
Primary source: FLYBASE:FBgn0264000
Locus tag: Dmel_CG43743
See related: AllianceGenome:FB:FBgn0264000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG42509; CG43743; CG4481; dglur-IB; DGluR-IB; DmelGlu-R1B; Dmel\CG43743; Dm_3L:43677; Glu-R1B; Glu-RIB; GluR1B; GluRIb
Old locus tag: Dmel_CG42509; Dmel_CG4481
Summary: Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission; modulation of chemical synaptic transmission; and monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of ionotropic glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in adult brain; adult head; and larval central nervous system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 67; autosomal recessive intellectual developmental disorder 76; epilepsy; schizophrenia; and syndromic X-linked intellectual disability 94. Orthologous to several human genes including GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Try the new Transcripts and proteins table

Genomic context

Location:: 67A4-67A6; 3-28 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9251978..9288522)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9245078..9281622)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables extracellular ligand-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ionotropic glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor IB

Names: CG43743-PA; CG43743-PB; CG43743-PC; CG43743-PD; GluRIB-PA; GluRIB-PB; GluRIB-PC; GluRIB-PD; glutamate receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9251978..9288522

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274693.1 → NP_001261622.1 glutamate receptor IB, isoform C

See identical proteins and their annotated locations for NP_001261622.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0C5KAS3, Q9TVG7, Q9VSV5

Conserved Domains (4) summary

cd06380
Location:43 → 478

PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor

cd13715
Location:497 → 938

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:632 → 967

Lig_chan; Ligand-gated ion channel

pfam01094
Location:55 → 461

ANF_receptor; Receptor family ligand binding region
NM_080016.4 → NP_524755.2 glutamate receptor IB, isoform A

See identical proteins and their annotated locations for NP_524755.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0C5KAS3, Q9TVG7, Q9VSV5

Related

FBpp0303372

Conserved Domains (4) summary

cd06380
Location:43 → 478

PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor

cd13715
Location:497 → 938

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:632 → 967

Lig_chan; Ligand-gated ion channel

pfam01094
Location:55 → 461

ANF_receptor; Receptor family ligand binding region
NM_001274692.1 → NP_001261621.2 glutamate receptor IB, isoform B

See identical proteins and their annotated locations for NP_001261621.2

Status: REVIEWED

UniProtKB/TrEMBL

M9PHV5, Q9TVG7

Conserved Domains (4) summary

cd06380
Location:43 → 478

PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor

cd13715
Location:497 → 938

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:632 → 967

Lig_chan; Ligand-gated ion channel

pfam01094
Location:55 → 461

ANF_receptor; Receptor family ligand binding region
NM_001316480.1 → NP_001303409.1 glutamate receptor IB, isoform D

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WIE7, Q9TVG7

Conserved Domains (4) summary

cd06380
Location:43 → 478

PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor

cd13715
Location:497 → 938

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:632 → 967

Lig_chan; Ligand-gated ion channel

pfam01094
Location:55 → 461

ANF_receptor; Receptor family ligand binding region