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arhgef7.S Rho guanine nucleotide exchange factor 7 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444424, updated on 5-Sep-2025
Official Symbol
arhgef7.S
Official Full Name
Rho guanine nucleotide exchange factor 7 S homeolog
Primary source
Xenbase:XB-GENE-17335880
Locus tag
XELAEV_18015601mg
See related
EnsemblRapid:ENSXLAG00005026549 AllianceGenome:Xenbase:XB-GENE-17335880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
p50; p85; pak3; pixb; cool1; arhgef7
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in lamellipodium. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Jul 2025]
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See arhgef7.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
26
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (107639972..107735002, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (98537725..98633122, complement)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 3 S homeolog Neighboring gene SRY-box 1 S homeolog Neighboring gene ankyrin repeat domain 10 S homeolog Neighboring gene inhibitor of growth family member 1 S homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC83025

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Rho guanine nucleotide exchange factor 7 S homeolog; rho guanine nucleotide exchange factor 7 S homeolog
Names
Rho guanine nucleotide exchange factor (GEF) 7

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092526.1 → NP_001085995.1  Rho guanine nucleotide exchange factor 7 S homeolog

    See identical proteins and their annotated locations for NP_001085995.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073669
    UniProtKB/TrEMBL
    Q6GN51
    Conserved Domains (4) summary
    cd12061
    Location:166 → 219
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21 → 100
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:250 → 423
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16615
    Location:127 → 162
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    107639972..107735002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041583125.1 → XP_041439059.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MBI3, A0A974DJG6
    Conserved Domains (7) summary
    cd12061
    Location:166 → 219
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    PHA03247
    Location:578 → 662
    PHA03247; large tegument protein UL36; Provisional
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:627 → 733
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:805 → 870
    DUF460; Protein of unknown function (DUF460)

  2. XM_041583128.1 → XP_041439062.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J1MBI5, A0A974DJG6
    Conserved Domains (7) summary
    cd12061
    Location:166 → 219
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    PHA03247
    Location:562 → 646
    PHA03247; large tegument protein UL36; Provisional
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 556
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:611 → 717
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:789 → 854
    DUF460; Protein of unknown function (DUF460)

  3. XM_041583126.1 → XP_041439060.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1MDA1, A0A974DJG6
    Conserved Domains (6) summary
    cd12061
    Location:164 → 217
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    PHA03247
    Location:576 → 660
    PHA03247; large tegument protein UL36; Provisional
    cd00160
    Location:248 → 425
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:456 → 570
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:625 → 731
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:803 → 868
    DUF460; Protein of unknown function (DUF460)

  4. XM_041583129.1 → XP_041439063.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X5

    UniProtKB/TrEMBL
    A0A8J1MBV3, A0A974DJG6
    Related
    ENSXLAP00005078917.1, ENSXLAT00005080507.1
    Conserved Domains (6) summary
    cd12061
    Location:166 → 219
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 556
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:611 → 710
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:782 → 847
    DUF460; Protein of unknown function (DUF460)

  5. XM_041583127.1 → XP_041439061.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1MCH7, A0A974DJG6
    Related
    ENSXLAP00005079221.1, ENSXLAT00005080812.1
    Conserved Domains (6) summary
    cd12061
    Location:166 → 219
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:627 → 726
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:798 → 863
    DUF460; Protein of unknown function (DUF460)

  6. XM_041583130.1 → XP_041439064.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X6

    UniProtKB/TrEMBL
    A0A8J1MBI7, A0A974DJG6
    Related
    ENSXLAP00005079370.1, ENSXLAT00005080961.1
    Conserved Domains (7) summary
    cd12061
    Location:166 → 219
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    PHA03247
    Location:578 → 662
    PHA03247; large tegument protein UL36; Provisional
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:627 → 733
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:746 → 811
    DUF460; Protein of unknown function (DUF460)

  7. XM_041583134.1 → XP_041439068.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X10

    UniProtKB/TrEMBL
    A0A8J1MBV9, A0A974DJG6
    Conserved Domains (7) summary
    cd12061
    Location:166 → 219
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    PHA03247
    Location:562 → 646
    PHA03247; large tegument protein UL36; Provisional
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 556
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:611 → 717
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:730 → 795
    DUF460; Protein of unknown function (DUF460)

  8. XM_018248275.2 → XP_018103764.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X7

    UniProtKB/TrEMBL
    A0A8J0UL31, A0A974DJG6
    Related
    ENSXLAP00005079653.1, ENSXLAT00005081244.1

  9. XM_041583133.1 → XP_041439067.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X9

    UniProtKB/TrEMBL
    A0A8J1MCI4, A0A974DJG6
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    PHA03247
    Location:422 → 506
    PHA03247; large tegument protein UL36; Provisional
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 416
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:471 → 577
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:649 → 714
    DUF460; Protein of unknown function (DUF460)

  10. XM_041583132.1 → XP_041439066.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X9

    UniProtKB/TrEMBL
    A0A8J1MCI4, A0A974DJG6
    Related
    ENSXLAP00005079525.1, ENSXLAT00005081116.1
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    PHA03247
    Location:422 → 506
    PHA03247; large tegument protein UL36; Provisional
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 416
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:471 → 577
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl27170
    Location:649 → 714
    DUF460; Protein of unknown function (DUF460)

  11. XM_041583131.1 → XP_041439065.1  rho guanine nucleotide exchange factor 7 S homeolog isoform X8

    UniProtKB/TrEMBL
    A0A8J1MDA7, A0A974DJG6
    Conserved Domains (6) summary
    cd12061
    Location:166 → 219
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    PHA03247
    Location:578 → 662
    PHA03247; large tegument protein UL36; Provisional
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:627 → 733
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
Nucleotide Protein Strain
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