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Hs2st Heparan sulfate 2-O-sulfotransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44433, updated on 4-Apr-2024

Summary

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Official Symbol
Hs2stprovided by FlyBase
Official Full Name
Heparan sulfate 2-O-sulfotransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0024230
Locus tag
Dmel_CG10234
See related
AllianceGenome:FB:FBgn0024230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10234; dHS2ST; Dmel\CG10234; dmHS-2OST; dmHs2st; DmHs2st; HS2ST; Hs2st-2
Summary
Enables heparan sulfate 2-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process and open tracheal system development. Predicted to be integral component of membrane. Is expressed in lamina furrow and organism. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Hs2st in Genome Data Viewer
Location:
37E1-37E1; 2-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19442833..19444750, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19442833..19444750, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rab9 Neighboring gene uncharacterized protein Neighboring gene Ran GTPase activating protein Neighboring gene Topoisomerase 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of Drosophila heparan sulfate 6-O-endosulfatase in sulfation compensation. Dejima K, et al. J Biol Chem, 2013 Mar 1. PMID 23339195, Free PMC Article
  2. Large-scale selective sweep among Segregation Distorter chromosomes in African populations of Drosophila melanogaster. Presgraves DC, et al. PLoS Genet, 2009 May. PMID 19412335, Free PMC Article
  3. Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. Xu D, et al. J Biol Chem, 2007 Mar 16. PMID 17227754
  4. In vivo manipulation of heparan sulfate structure and its effect on Drosophila development. Kamimura K, et al. Glycobiology, 2011 May. PMID 21147759, Free PMC Article
  5. Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila. Merrill C, et al. Science, 1999 Mar 12. PMID 10073941

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heparan sulfate 2-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparan sulfate 2-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in open tracheal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heparan sulfate 2-O-sulfotransferase
Names
2-O sulfotransferase
CG10234-PA
HS 2-O
HS 2-O-sulfotransferase
Hs2st-PA
heparan-sulfate-2-sulfotransferase
NP_477339.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19442833..19444750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057991.5 → NP_477339.1  heparan sulfate 2-O-sulfotransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25722, Q9VIW4
    Related
    FBpp0080826
    Conserved Domains (1) summary
    pfam03567
    Location:70 → 325
    Sulfotransfer_2; Sulfotransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25722.2 P25722

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