U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cbp80 cap binding protein 80 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44409, updated on 9-Mar-2023

Summary

Official Symbol
Cbp80provided by FlyBase
Official Full Name
cap binding protein 80provided by FlyBase
Primary source
FLYBASE:FBgn0022942
Locus tag
Dmel_CG7035
See related
AllianceGenome:FB:FBgn0022942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cbp80; CBP80; CG7035; Dmel\CG7035; EG:84H4.3
Summary
Predicted to enable RNA cap binding activity and mRNA binding activity. Involved in negative regulation of viral genome replication; primary miRNA processing; and production of siRNA involved in RNA interference. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; organism; and ovary. Orthologous to human NCBP1 (nuclear cap binding protein subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cbp80 in Genome Data Viewer
Location:
4C11-4C11; 1-8 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4650015..4658259)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4544048..4552292)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Helix loop helix protein 4C Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene torsin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene fizzy-related Neighboring gene Protein phosphatase 2C

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA cap binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of mRNA cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear cap binding complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of precatalytic spliceosome HDA PubMed 
located_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cap binding protein 80
Names
CG7035-PA
CG7035-PB
Cap binding protein 80
Cap-binding protein 80
Cbp80-PA
Cbp80-PB

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4650015..4658259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167012.3NP_726938.1  cap binding protein 80, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726938.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K4N3, Q9U980
    UniProtKB/TrEMBL
    E2QD75
    Related
    FBpp0070651, FBtr0070683
    Conserved Domains (3) summary
    smart00543
    Location:31243
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam09088
    Location:307473
    MIF4G_like; MIF4G like
    pfam09090
    Location:494764
    MIF4G_like_2; MIF4G like
  2. NM_080011.3NP_524750.2  cap binding protein 80, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524750.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K4N3, Q9U980
    UniProtKB/TrEMBL
    E2QD75
    Related
    FBpp0070652, FBtr0070684
    Conserved Domains (3) summary
    smart00543
    Location:31243
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam09088
    Location:307473
    MIF4G_like; MIF4G like
    pfam09090
    Location:494764
    MIF4G_like_2; MIF4G like