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ASPH aspartate beta-hydroxylase [ Homo sapiens (human) ]

Gene ID: 444, updated on 13-Jan-2019

Summary

Official Symbol
ASPHprovided by HGNC
Official Full Name
aspartate beta-hydroxylaseprovided by HGNC
Primary source
HGNC:HGNC:757
See related
Ensembl:ENSG00000198363 MIM:600582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAH; BAH; HAAH; JCTN; FDLAB; junctin; CASQ2BP1
Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Expression
Broad expression in fat (RPKM 85.5), adrenal (RPKM 27.8) and 21 other tissues See more
Orthologs

Genomic context

See ASPH in Genome Data Viewer
Location:
8q12.3
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (61500556..61714640, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (62413115..62627199, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene clavesin 1 Neighboring gene nucleophosmin 1 pseudogene 6 Neighboring gene uncharacterized LOC105375870 Neighboring gene keratin 8 pseudogene 3 Neighboring gene RNA, 7SK small nuclear pseudogene 97 Neighboring gene CAGE-defined mid-level expression enhancer upstream of ASPH Neighboring gene microRNA 4470

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ASPH; predicted interaction to be within the endoplasmic reticulum PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Ion homeostasis, organism-specific biosystem (from REACTOME)
    Ion homeostasis, organism-specific biosystemIon channel homeostasis in relation to cardiac conduction is described in this section (Couette et al. 2006, Bartos et al. 2015).
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
peptide-aspartate beta-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
pattern specification process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-aspartic acid hydroxylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of protein depolymerization IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aspartyl/asparaginyl beta-hydroxylase
Names
A beta H-J-J
ASP beta-hydroxylase
cardiac junctin
humbug
junctate
peptide-aspartate beta-dioxygenase
NP_001158222.1
NP_001158223.1
NP_001158224.1
NP_001158225.1
NP_001158226.1
NP_001158227.1
NP_001158228.1
NP_004309.2
NP_064549.1
NP_115855.1
NP_115856.1
NP_115857.1
XP_005251292.1
XP_005251293.1
XP_005251296.1
XP_005251297.1
XP_005251299.1
XP_005251300.1
XP_005251301.1
XP_005251303.1
XP_005251304.1
XP_016868908.1
XP_016868909.1
XP_016868910.1
XP_016868911.1
XP_016868913.1
XP_016868914.1
XP_016868915.1
XP_016868916.1
XP_016868917.1
XP_016868918.1
XP_016868919.1
XP_016868920.1
XP_016868921.1
XP_016868922.1
XP_016868923.1
XP_016868924.1
XP_016868926.1
XP_016868927.1
XP_016868928.1
XP_016868929.1
XP_016868933.1
XP_016868934.1
XP_016868935.1
XP_016868936.1
XP_024302923.1
XP_024302924.1
XP_024302925.1
XP_024302926.1
XP_024302927.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013210.1 RefSeqGene

    Range
    5001..219085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164750.1NP_001158222.1  aspartyl/asparaginyl beta-hydroxylase isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, compared to variant 1. The resulting isoform (f) has a shorter and distinct N-terminus, compared to isoform a. This isoform includes the beta-hydroxylase domain found in isoform a and is likely to have catalytic activity.
    Source sequence(s)
    AC090094, AF339775, AK304314, BC025236, DN993915, S83325
    Consensus CDS
    CCDS55234.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000437864.1, ENST00000541428.5
    Conserved Domains (5) summary
    TIGR02795
    Location:313426
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14281
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:429453
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:562715
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:316355
    TPR_14; Tetratricopeptide repeat
  2. NM_001164751.1NP_001158223.1  aspartyl/asparaginyl beta-hydroxylase isoform g

    See identical proteins and their annotated locations for NP_001158223.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, uses a distinct 3' splice pattern that lacks many coding exons, includes an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (g) has a shorter and distinct N-terminus a substantially shorter and distinct C-terminus, and several internal differences, compared to isoform a. This isoform is similar to isoform b, which is also known as junctate.
    Source sequence(s)
    AC067881, BC144362, BU623111, DN993915
    Consensus CDS
    CCDS55236.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000430245.1, ENST00000517903.5
    Conserved Domains (1) summary
    pfam05279
    Location:14295
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  3. NM_001164752.1NP_001158224.1  aspartyl/asparaginyl beta-hydroxylase isoform h

    See identical proteins and their annotated locations for NP_001158224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, uses a distinct 3' splice pattern that lacks many coding exons, includes an alternate in-frame exon, lacks an alternate in-frame exon, and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (h) has a shorter and distinct N-terminus a substantially shorter and distinct C-terminus, and several internal differences, compared to isoform a. This isoform is similar to isoform b, which is also known as junctate.
    Source sequence(s)
    AC067881, BC144363, BU623111, DN993915
    UniProtKB/TrEMBL
    B7ZM96
    Conserved Domains (1) summary
    pfam05279
    Location:14276
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  4. NM_001164753.1NP_001158225.1  aspartyl/asparaginyl beta-hydroxylase isoform i

    See identical proteins and their annotated locations for NP_001158225.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, uses a distinct 3' splice pattern that lacks many coding exons, includes an alternate in-frame exon, and lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (i) has a shorter and distinct N-terminus a substantially shorter and distinct C-terminus, and several internal differences, compared to isoform a. This isoform is similar to isoform b, which is also known as junctate.
    Source sequence(s)
    AC067881, AK295528, BU623111, DN993915
    Consensus CDS
    CCDS55235.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000429160.1, ENST00000522835.5
    Conserved Domains (1) summary
    pfam05279
    Location:14253
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  5. NM_001164754.1NP_001158226.1  aspartyl/asparaginyl beta-hydroxylase isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks an alternate in-frame exon and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The resulting isoform (j) lacks an internal segment and has a substantially shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC067881, AK298577, BU623111, DA136318
    Consensus CDS
    CCDS75746.1
    UniProtKB/TrEMBL
    B4DQ07
    Related
    ENSP00000394013.4, ENST00000445642.6
    Conserved Domains (1) summary
    pfam05279
    Location:43291
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  6. NM_001164755.1NP_001158227.1  aspartyl/asparaginyl beta-hydroxylase isoform k

    See identical proteins and their annotated locations for NP_001158227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an alternate in-frame exon and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The resulting isoform (k) lacks an internal segment and has a substantially shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC067881, BC025236, BU623111
    Consensus CDS
    CCDS55237.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000429286.1, ENST00000518068.5
    Conserved Domains (1) summary
    pfam05279
    Location:43267
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  7. NM_001164756.1NP_001158228.1  aspartyl/asparaginyl beta-hydroxylase isoform l

    See identical proteins and their annotated locations for NP_001158228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) includes an alternate in-frame exon and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The resulting isoform (l) includes an alternate segment and has a substantially shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC066929, BU741737, CR996516, DA136318
    Consensus CDS
    CCDS55238.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000368762.5, ENST00000379449.10
    Conserved Domains (1) summary
    pfam05279
    Location:43146
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  8. NM_004318.4NP_004309.2  aspartyl/asparaginyl beta-hydroxylase isoform a

    See identical proteins and their annotated locations for NP_004309.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform. The distinct C-terminus of this isoform has enzymatic activity which hydroxylates the beta carbon of aspartic acid or asparagine residues in certain epidermal growth factor-like domains of proteins such as protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. This variant is widely expressed among heart, placenta, skeletal muscle, kidney, and lung tissues.
    Source sequence(s)
    AC067881, AC090094, S83325, U03109
    Consensus CDS
    CCDS34898.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000368767.4, ENST00000379454.8
    Conserved Domains (5) summary
    TIGR02795
    Location:342455
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43310
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:458482
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:591744
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:345384
    TPR_14; Tetratricopeptide repeat
  9. NM_020164.4NP_064549.1  aspartyl/asparaginyl beta-hydroxylase isoform e

    See identical proteins and their annotated locations for NP_064549.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR, uses a distinct start codon, includes an alternate in-frame exon, and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The encoded isoform (e) has a slightly shorter and distinct N-terminus and some overlap with the N-terminus of isoform a. This isoform lacks the catalytic domain and enzymatic function of isoform a. This isoform has also been referred to as junctin isoform 1 and forms a complex with calsequestrin, triadin, and the ryanodine receptor by direct interaction at the C-terminal part of the molecule. This protein appears to stabilize the complex and plays a crucial role in the regulation of calcium release from the sarcoplasmic reticulum. This variant is expressed in cardiac and skeletal muscle.
    Source sequence(s)
    AC067881, AF224469, BX102882, DN993915
    Consensus CDS
    CCDS34900.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000373856.4, ENST00000389204.8
    Conserved Domains (1) summary
    pfam05279
    Location:14205
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  10. NM_032466.3NP_115855.1  aspartyl/asparaginyl beta-hydroxylase isoform c

    See identical proteins and their annotated locations for NP_115855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The encoded isoform (c), also known as humbug, is identical to the N-terminal and central region of isoform a. Because this transcript variant lacks the alternative 3' terminal exon which encodes a catalytic domain for isoform a, isoform c is considered a noncatalytic isoform. This variant is widely expressed among heart, placenta, skeletal muscle, kidney, and lung tissues.
    Source sequence(s)
    AC067881, AF289489, BC025236, BU623111
    Consensus CDS
    CCDS43742.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000348841.5, ENST00000356457.9
    Conserved Domains (1) summary
    pfam05279
    Location:43310
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  11. NM_032467.3NP_115856.1  aspartyl/asparaginyl beta-hydroxylase isoform d

    See identical proteins and their annotated locations for NP_115856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses a distinct start codon, and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The encoded isoform (d) has a slightly shorter and distinct N-terminus and some overlap with the N-terminus of isoform a, but lacks the catalytic domain and enzymatic function of isoform a. This isoform has also been referred to as junctin and forms a complex with calsequestrin, triadin, and the ryanodine receptor by direct interaction at the C-terminal part of the molecule. This protein appears to stabilize the complex and plays a crucial role in the regulation of calcium release from the sarcoplasmic reticulum. This variant is expressed in cardiac and skeletal muscle.
    Source sequence(s)
    AC067881, AF224468, BX102882, DN993915
    Consensus CDS
    CCDS34899.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000436188.1, ENST00000522603.5
    Conserved Domains (1) summary
    pfam05279
    Location:14190
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  12. NM_032468.4NP_115857.1  aspartyl/asparaginyl beta-hydroxylase isoform b

    See identical proteins and their annotated locations for NP_115857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a distinct start codon, includes an alternate in-frame exon, and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The encoded isoform (b) shares residues with the central region of isoform a. This isoform lacks the catalytic domain and enzymatic function of isoform a. Isoform b has also been referred to as junctate and is located in both the endoplasmic and sarcoplasmic reticulum. Calcium binding properties of this isoform suggest an active role in the calcium storage and release process in the endoplasmic reticulum. This variant is expressed in heart, brain, pancreas, placenta, lung, liver, kidney, and skeletal muscle tissues.
    Source sequence(s)
    AC067881, AF306765, BU623111, DN993915
    Consensus CDS
    CCDS47866.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000429954.2, ENST00000517847.6
    Conserved Domains (1) summary
    pfam05279
    Location:14296
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    61500556..61714640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251247.2XP_005251304.1  aspartyl/asparaginyl beta-hydroxylase isoform X31

    Conserved Domains (5) summary
    TIGR02795
    Location:295408
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43263
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:411435
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:544697
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:298337
    TPR_14; Tetratricopeptide repeat
  2. XM_024447155.1XP_024302923.1  aspartyl/asparaginyl beta-hydroxylase isoform X23

    Conserved Domains (5) summary
    pfam05279
    Location:43263
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:411435
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:544724
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    cl26250
    Location:295408
    TPR_6; Tetratricopeptide repeat
    cl27017
    Location:318506
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
  3. XM_017013438.1XP_016868927.1  aspartyl/asparaginyl beta-hydroxylase isoform X26

  4. XM_017013432.1XP_016868921.1  aspartyl/asparaginyl beta-hydroxylase isoform X15

  5. XM_005251243.2XP_005251300.1  aspartyl/asparaginyl beta-hydroxylase isoform X25

    Conserved Domains (5) summary
    TIGR02795
    Location:314427
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43282
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:430454
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:563716
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:317356
    TPR_14; Tetratricopeptide repeat
  6. XM_017013430.1XP_016868919.1  aspartyl/asparaginyl beta-hydroxylase isoform X13

  7. XM_017013434.1XP_016868923.1  aspartyl/asparaginyl beta-hydroxylase isoform X18

  8. XM_005251239.2XP_005251296.1  aspartyl/asparaginyl beta-hydroxylase isoform X17

    Conserved Domains (5) summary
    TIGR02795
    Location:338451
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43306
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:454478
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:587740
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:341380
    TPR_14; Tetratricopeptide repeat
  9. XM_017013425.1XP_016868914.1  aspartyl/asparaginyl beta-hydroxylase isoform X6

  10. XM_017013421.1XP_016868910.1  aspartyl/asparaginyl beta-hydroxylase isoform X3

  11. XM_005251236.2XP_005251293.1  aspartyl/asparaginyl beta-hydroxylase isoform X8

    Conserved Domains (5) summary
    TIGR02795
    Location:356469
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43324
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:472496
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:605758
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:359398
    TPR_14; Tetratricopeptide repeat
  12. XM_017013420.1XP_016868909.1  aspartyl/asparaginyl beta-hydroxylase isoform X2

  13. XM_005251235.2XP_005251292.1  aspartyl/asparaginyl beta-hydroxylase isoform X7

    Conserved Domains (5) summary
    TIGR02795
    Location:357470
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43325
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:473497
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:606759
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:360399
    TPR_14; Tetratricopeptide repeat
  14. XM_017013419.1XP_016868908.1  aspartyl/asparaginyl beta-hydroxylase isoform X1

  15. XM_005251246.3XP_005251303.1  aspartyl/asparaginyl beta-hydroxylase isoform X30

    Conserved Domains (5) summary
    TIGR02795
    Location:299412
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43267
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:415439
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:548701
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:302341
    TPR_14; Tetratricopeptide repeat
  16. XM_017013437.2XP_016868926.1  aspartyl/asparaginyl beta-hydroxylase isoform X21

  17. XM_005251242.3XP_005251299.1  aspartyl/asparaginyl beta-hydroxylase isoform X22

    Conserved Domains (5) summary
    TIGR02795
    Location:323436
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43291
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:439463
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:572725
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:326365
    TPR_14; Tetratricopeptide repeat
  18. XM_017013428.2XP_016868917.1  aspartyl/asparaginyl beta-hydroxylase isoform X11

  19. XM_017013429.2XP_016868918.1  aspartyl/asparaginyl beta-hydroxylase isoform X12

  20. XM_017013424.2XP_016868913.1  aspartyl/asparaginyl beta-hydroxylase isoform X5

  21. XM_017013422.2XP_016868911.1  aspartyl/asparaginyl beta-hydroxylase isoform X4

  22. XM_017013440.1XP_016868929.1  aspartyl/asparaginyl beta-hydroxylase isoform X28

  23. XM_005251244.1XP_005251301.1  aspartyl/asparaginyl beta-hydroxylase isoform X29

    Conserved Domains (5) summary
    TIGR02795
    Location:308421
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14276
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:424448
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:557710
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:311350
    TPR_14; Tetratricopeptide repeat
  24. XM_017013435.1XP_016868924.1  aspartyl/asparaginyl beta-hydroxylase isoform X19

  25. XM_017013427.1XP_016868916.1  aspartyl/asparaginyl beta-hydroxylase isoform X10

  26. XM_005251240.1XP_005251297.1  aspartyl/asparaginyl beta-hydroxylase isoform X20

    Conserved Domains (5) summary
    TIGR02795
    Location:328441
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14296
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:444468
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:577730
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:331370
    TPR_14; Tetratricopeptide repeat
  27. XM_017013426.1XP_016868915.1  aspartyl/asparaginyl beta-hydroxylase isoform X9

  28. XM_017013444.1XP_016868933.1  aspartyl/asparaginyl beta-hydroxylase isoform X32

  29. XM_024447156.1XP_024302924.1  aspartyl/asparaginyl beta-hydroxylase isoform X24

    Conserved Domains (5) summary
    pfam05279
    Location:14262
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:410434
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:543723
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    cl26250
    Location:294407
    TPR_6; Tetratricopeptide repeat
    cl27017
    Location:317505
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
  30. XM_017013439.1XP_016868928.1  aspartyl/asparaginyl beta-hydroxylase isoform X27

  31. XM_017013433.1XP_016868922.1  aspartyl/asparaginyl beta-hydroxylase isoform X16

  32. XM_017013431.1XP_016868920.1  aspartyl/asparaginyl beta-hydroxylase isoform X14

  33. XM_024447157.1XP_024302925.1  aspartyl/asparaginyl beta-hydroxylase isoform X33

    Conserved Domains (1) summary
    pfam05279
    Location:43310
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  34. XM_024447158.1XP_024302926.1  aspartyl/asparaginyl beta-hydroxylase isoform X34

    Conserved Domains (1) summary
    pfam05279
    Location:14281
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  35. XM_017013447.1XP_016868936.1  aspartyl/asparaginyl beta-hydroxylase isoform X37

    Related
    ENSP00000427877.1, ENST00000518306.5
  36. XM_017013446.1XP_016868935.1  aspartyl/asparaginyl beta-hydroxylase isoform X36

  37. XM_017013445.1XP_016868934.1  aspartyl/asparaginyl beta-hydroxylase isoform X35

  38. XM_024447159.1XP_024302927.1  aspartyl/asparaginyl beta-hydroxylase isoform X38

    Related
    ENSP00000428060.1, ENST00000517661.5
    Conserved Domains (1) summary
    pfam05279
    Location:14117
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
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