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PPARA peroxisome proliferator activated receptor alpha [ Ovis aries (sheep) ]

Gene ID: 443457, updated on 5-Mar-2024

Summary

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Gene symbol
PPARA
Gene description
peroxisome proliferator activated receptor alpha
See related
EnsemblRapid:ENSOARG00020002103
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
PPAR ALPHA
Orthologs
human mouse all
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Genomic context

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See PPARA in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 3 NC_056056.1 (222351747..222422559)

Chromosome 3 - NC_056056.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121819244 Neighboring gene uncharacterized LOC121819243 Neighboring gene microRNA let-7b Neighboring gene uncharacterized LOC121819246 Neighboring gene uncharacterized LOC114114095 Neighboring gene polycystin family receptor for egg jelly-like Neighboring gene cysteine rich DPF motif domain containing 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Ovis aries Rambouillet Genome sequencing and assembly
  • BioProject: PRJNA414087
  • Analysis date: Thu Jan 09 10:41:41 2025

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peroxisome proliferator-activated receptor alpha
Names
proliferator-activated receptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056056.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    222351747..222422559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027968213.2 → XP_027824014.2  peroxisome proliferator-activated receptor alpha isoform X2

    UniProtKB/TrEMBL
    W5QDS1
    Related
    ENSOARP00020049083.1, ENSOART00020078161.1
    Conserved Domains (2) summary
    cd06932
    Location:203 → 469
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:103 → 186
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

  2. XM_042247880.1 → XP_042103814.1  peroxisome proliferator-activated receptor alpha isoform X1

    Conserved Domains (2) summary
    cd06965
    Location:103 → 186
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    cl11397
    Location:203 → 393
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  3. XM_042247881.2 → XP_042103815.1  peroxisome proliferator-activated receptor alpha isoform X1

    Conserved Domains (2) summary
    cd06965
    Location:103 → 186
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    cl11397
    Location:203 → 393
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
Nucleotide Protein Strain
Heading Accession and Version

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