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PDXK pyridoxal kinase [ Ovis aries (sheep) ]

Gene ID: 443049, updated on 10-Sep-2025
Gene symbol
PDXK
Gene description
pyridoxal kinase
See related
Ensembl:ENSOARG00020070708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
PKH
Orthologs
human mouse all
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See PDXK in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 1 NC_056054.1 (264462662..264493143)

Chromosome 1 - NC_056054.1Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 2 binding protein Neighboring gene ribosomal RNA processing 1B Neighboring gene uncharacterized LOC114110470 Neighboring gene stefin-C Neighboring gene cystatin-B

Genomic Sequence:
NC_056054.1 Chromosome 1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Ovis aries Rambouillet Genome sequencing and assembly
  • BioProject: PRJNA414087
  • Analysis date: Thu Jan 09 10:41:41 2025

Related articles in PubMed

  1. Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily. Li MH, et al. J Biol Chem, 2002 Nov 29. PMID 12235162
  2. Crystallization and preliminary crystallographic studies of pyridoxal kinase from sheep brain. Li MH, et al. Acta Crystallogr D Biol Crystallogr, 2002 Sep. PMID 12198308
  3. Structure of pyridoxal kinase from sheep brain and role of the tryptophanyl residues. Maras B, et al. J Protein Chem, 1999 Apr. PMID 10395444
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables pyridoxal kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in pyridoxal 5'-phosphate salvage IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
pyridoxal kinase
Names
pyridoxal (pyridoxine, vitamin B6) kinase
pyridoxine kinase
NP_001009220.1
XP_027822412.1
XP_060267260.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009220.1 → NP_001009220.1  pyridoxal kinase

    See identical proteins and their annotated locations for NP_001009220.1

    Status: PROVISIONAL

    Source sequence(s)
    AF125374
    UniProtKB/TrEMBL
    W5PNY4
    Conserved Domains (1) summary
    cl00192
    Location:33 → 289
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056054.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    264462662..264493143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_060411277.1 → XP_060267260.1  pyridoxal kinase isoform X1

    UniProtKB/Swiss-Prot
    P82197, Q9XSD8

  2. XM_027966611.2 → XP_027822412.1  pyridoxal kinase isoform X2

    UniProtKB/Swiss-Prot
    P82197, Q9XSD8
    UniProtKB/TrEMBL
    A0A6P7DUD2
    Related
    ENSOARP00020080611.1, ENSOART00020174330.1
    Conserved Domains (1) summary
    cl00192
    Location:6 → 304
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82197.1 GenPept UniProtKB/Swiss-Prot:P82197

Gene LinkOut

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Molecular Biology Databases
Research Materials