UTRN utrophin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: UTRNprovided by VGNC
Official Full Name: utrophinprovided by VGNC
Primary source: VGNC:VGNC:48215
See related: Ensembl:ENSCAFG00845012944 RGD:12410885
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 80

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (35906556..36401715)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (36627086..37115507)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (35969567..36458179)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (35775436..36264006)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (35651671..36139451)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings support a model in which utrophin-derived therapies might be used to treat clinical dystrophin deficiency, with a favorable immunologic profile and preserved function in the face of extreme miniaturization.
Title: Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models.
Utrophin was highly upregulated in the earlier stage of CXMD(J) Purkinje fibers, but the expression was dislocated when vacuolar degeneration was recognized at 4 months of age
Title: Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in synaptic signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: utrophin

Names: urotrophin; utrophin (homologous to dystrophin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012395.1 → NP_001012395.1 utrophin

See identical proteins and their annotated locations for NP_001012395.1

Status: PROVISIONAL

Source sequence(s)

AY095485

UniProtKB/TrEMBL

A0A8I3NQX0, Q5JCF5

Related

ENSCAFP00845018101.1, ENSCAFT00845023087.1

Conserved Domains (7) summary

cd00014
Location:32 → 135

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:310 → 528

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2817 → 2845

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3068 → 3116

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:2846 → 2964

EF-hand_2; EF hand

pfam09069
Location:2968 → 3059

EF-hand_3; EF-hand

cl02488
Location:2230 → 2442

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051805.1 Reference ROS_Cfam_1.0

Range

35906556..36401715

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038653449.1 → XP_038509377.1 utrophin isoform X6

UniProtKB/TrEMBL

A0A8I3NQX0

Conserved Domains (7) summary

cd00176
Location:310 → 528

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2817 → 2845

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3068 → 3116

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2882 → 3043

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:31 → 137

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:152 → 255

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:2230 → 2442

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653443.1 → XP_038509371.1 utrophin isoform X2

UniProtKB/TrEMBL

A0A8C0QXY2

Conserved Domains (7) summary

cd00176
Location:310 → 528

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2817 → 2845

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3068 → 3116

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2882 → 3043

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:31 → 137

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:152 → 255

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:1466 → 1648

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653444.1 → XP_038509372.1 utrophin isoform X2

UniProtKB/TrEMBL

A0A8C0QXY2

Conserved Domains (7) summary

cd00176
Location:310 → 528

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2817 → 2845

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3068 → 3116

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2882 → 3043

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:31 → 137

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:152 → 255

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:1466 → 1648

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653445.1 → XP_038509373.1 utrophin isoform X2

UniProtKB/TrEMBL

A0A8C0QXY2

Conserved Domains (7) summary

cd00176
Location:310 → 528

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2817 → 2845

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3068 → 3116

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2882 → 3043

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:31 → 137

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:152 → 255

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:1466 → 1648

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653447.1 → XP_038509375.1 utrophin isoform X4

UniProtKB/TrEMBL

A0A8C0QXY2

Conserved Domains (7) summary

cd00176
Location:301 → 519

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2808 → 2836

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3059 → 3107

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2873 → 3034

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:22 → 128

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:143 → 246

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:1457 → 1639

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653446.1 → XP_038509374.1 utrophin isoform X3

UniProtKB/TrEMBL

A0A8C0QXY2

Conserved Domains (7) summary

cd00176
Location:315 → 533

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2822 → 2850

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3073 → 3121

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2887 → 3048

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:36 → 142

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:157 → 260

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:1471 → 1653

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653448.1 → XP_038509376.1 utrophin isoform X5

UniProtKB/TrEMBL

A0A8I3NQX0

Conserved Domains (7) summary

cd00176
Location:315 → 533

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2822 → 2850

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3073 → 3121

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2887 → 3048

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:36 → 142

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:157 → 260

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:1471 → 1653

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653442.1 → XP_038509370.1 utrophin isoform X1

UniProtKB/TrEMBL

A0A8C0QXY2

Conserved Domains (7) summary

cd00176
Location:315 → 533

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2822 → 2850

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3073 → 3121

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2887 → 3048

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:36 → 142

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:157 → 260

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:1471 → 1653

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653450.1 → XP_038509378.1 utrophin isoform X7

UniProtKB/TrEMBL

A0A8I3NQX0

Conserved Domains (7) summary

cd00176
Location:315 → 533

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2822 → 2850

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3073 → 3121

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:2887 → 3048

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:36 → 142

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:157 → 260

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:2235 → 2447

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038653451.1 → XP_038509379.1 utrophin isoform X8

UniProtKB/TrEMBL

A0A8I3NND2

Related

ENSCAFP00845018264.1, ENSCAFT00845023283.1

Conserved Domains (4) summary

cd00176
Location:44 → 245

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:372 → 400

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:623 → 671

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:437 → 598

EFh_UTRO; EF-hand-like motif found in utrophin
XM_038653452.1 → XP_038509380.1 utrophin isoform X9

UniProtKB/TrEMBL

A0A8I3NDA9, A0A8I3NND2

Related

ENSCAFP00845018299.1, ENSCAFT00845023323.1

Conserved Domains (4) summary

cd00176
Location:44 → 245

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:372 → 400

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:623 → 671

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:437 → 598

EFh_UTRO; EF-hand-like motif found in utrophin