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PTGS2 prostaglandin-endoperoxide synthase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 442942, updated on 23-Oct-2016
Gene symbol
PTGS2
Gene description
prostaglandin-endoperoxide synthase 2
See related
Ensembl:ENSCAFG00000013762
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
COX-2
Orthologs
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
104 current CanFam3.1 (GCF_000002285.3) 7 NC_006589.3 (19668079..19674953, complement)

Chromosome 7 - NC_006589.3Genomic Context describing neighboring genes Neighboring gene YTH domain-containing family protein 1-like Neighboring gene mitochondrial fission regulator 1-like Neighboring gene non-POU domain-containing octamer-binding protein pseudogene Neighboring gene uncharacterized LOC102153640

Genomic Sequence:
NC_006589.3 Chromosome 7 Reference CanFam3.1 Primary Assembly

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
    Arachidonic acid metabolism, organism-specific biosystem
    Arachidonic acid metabolism
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Arachidonic acid metabolism, conserved biosystem (from KEGG)
    Arachidonic acid metabolism, conserved biosystem
    Arachidonic acid metabolism
  • Chemical carcinogenesis, organism-specific biosystem (from KEGG)
    Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Chemical carcinogenesis, conserved biosystem (from KEGG)
    Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
    Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
  • Leishmaniasis, organism-specific biosystem (from KEGG)
    Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Nicotinamide salvaging, organism-specific biosystem (from REACTOME)
    Nicotinamide salvaging, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nicotinate metabolism, organism-specific biosystem (from REACTOME)
    Nicotinate metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
    Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Ovarian steroidogenesis, conserved biosystem (from KEGG)
    Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
    Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Synthesis of 15-eicosatetraenoic acid derivatives, organism-specific biosystem (from REACTOME)
    Synthesis of 15-eicosatetraenoic acid derivatives, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Synthesis of Prostaglandins (PG) and Thromboxanes (TX), organism-specific biosystem (from REACTOME)
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • VEGF signaling pathway, organism-specific biosystem (from KEGG)
    VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGF signaling pathway, conserved biosystem (from KEGG)
    VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...

Markers

Homology

Preferred Names
prostaglandin G/H synthase 2
Names
cyclooxygenase 2
cyclooxygenase type 2
prostaglandin G/H synthase-2
NP_001003354.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003354.1NP_001003354.1  prostaglandin G/H synthase 2 precursor

    See identical proteins and their annotated locations for NP_001003354.1

    Status: PROVISIONAL

    Source sequence(s)
    AY044905
    UniProtKB/TrEMBL
    Q8SPQ9
    Related
    ENSCAFP00000020288, ENSCAFT00000021841
    Conserved Domains (2) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1954
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

  1. NC_006589.3 Reference CanFam3.1 Primary Assembly

    Range
    19668079..19674953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005622227.2XP_005622284.1  

    See identical proteins and their annotated locations for XP_005622284.1

    UniProtKB/TrEMBL
    Q8SPQ9
    Related
    ENSCAFP00000038440, ENSCAFT00000044614
    Conserved Domains (2) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1954
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_005622228.2XP_005622285.1  

    Conserved Domains (1) summary
    cd09816
    Location:43530
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
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