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MIR374A microRNA 374a [ Homo sapiens (human) ]

Gene ID: 442919, updated on 24-Nov-2020


Official Symbol
MIR374Aprovided by HGNC
Official Full Name
microRNA 374aprovided by HGNC
Primary source
See related
Ensembl:ENSG00000199168 miRBase:MI0000782
Gene type
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN374; MIRN374A; mir-374a; hsa-mir-374
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

See MIR374A in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (74287286..74287357, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (73507121..73507192, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene FTX transcript, XIST regulator Neighboring gene RNA, 7SL, cytoplasmic 648, pseudogene Neighboring gene microRNA 545 Neighboring gene zinc finger CCHC-type containing 13 Neighboring gene NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) pseudogene

Genomic regions, transcripts, and products


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Other Names

  • hsa-mir-374a
  • microRNA 374

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
mRNA binding involved in posttranscriptional gene silencing IDA
Inferred from Direct Assay
more info
Process Evidence Code Pubs
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
negative regulation of cell adhesion molecule production IDA
Inferred from Direct Assay
more info
Component Evidence Code Pubs
extracellular space HDA PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NR_030785.1 RNA Sequence


    Source sequence(s)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    74287286..74287357 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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