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Defb22 defensin beta 22 [ Mus musculus (house mouse) ]

Gene ID: 442835, updated on 5-Mar-2024

Summary

Official Symbol
Defb22provided by MGI
Official Full Name
defensin beta 22provided by MGI
Primary source
MGI:MGI:3045368
See related
Ensembl:ENSMUSG00000027468 AllianceGenome:MGI:3045368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9230002F21Rik
Summary
Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to Gram-negative bacterium. Located in cell surface and glycocalyx. Orthologous to human DEFB126 (defensin beta 126). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward genital fat pad adult (RPKM 150.5) See more
Orthologs
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Genomic context

Location:
2 H1; 2 75.13 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152327586..152332058, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152485666..152490138, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_06062 Neighboring gene defensin beta 20 Neighboring gene defensin beta 26 Neighboring gene defensin beta 28

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General protein information

Preferred Names
beta-defensin 22
Names
beta-defensin 126

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002791.2NP_001002791.1  beta-defensin 22 precursor

    See identical proteins and their annotated locations for NP_001002791.1

    Status: VALIDATED

    Source sequence(s)
    DQ012033
    Consensus CDS
    CCDS16887.1
    UniProtKB/Swiss-Prot
    Q8BVC1
    Related
    ENSMUSP00000028966.3, ENSMUST00000028966.3
    Conserved Domains (1) summary
    pfam13841
    Location:2659
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152327586..152332058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)