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LMOD2 leiomodin 2 [ Homo sapiens (human) ]

Gene ID: 442721, updated on 11-Jun-2021

Summary

Official Symbol
LMOD2provided by HGNC
Official Full Name
leiomodin 2provided by HGNC
Primary source
HGNC:HGNC:6648
See related
Ensembl:ENSG00000170807 MIM:608006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLMOD; C-LMOD
Expression
Restricted expression toward heart (RPKM 307.4) See more
Orthologs
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Genomic context

See LMOD2 in Genome Data Viewer
Location:
7q31.32
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (123655866..123664290)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123295920..123304344)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene ankyrin repeat and SOCS box containing 15 Neighboring gene ASB15 antisense RNA 1 Neighboring gene WASP like actin nucleation promoting factor Neighboring gene WASL divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin monomer binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tropomyosin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with M band IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leiomodin-2
Names
cardiac leiomodin
leiomodin 2 (cardiac)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207163.3NP_997046.1  leiomodin-2

    See identical proteins and their annotated locations for NP_997046.1

    Status: VALIDATED

    Source sequence(s)
    AA747115, AC006333, BC017911
    Consensus CDS
    CCDS47693.1
    UniProtKB/Swiss-Prot
    Q6P5Q4
    Related
    ENSP00000411932.2, ENST00000458573.3
    Conserved Domains (2) summary
    cd00116
    Location:223332
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:685
    Tropomodulin; Tropomodulin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    123655866..123664290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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