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sut2 sugar transporter 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44269, updated on 4-Jan-2025

Summary

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Official Symbol
sut2provided by FlyBase
Official Full Name
sugar transporter 2provided by FlyBase
Primary source
FLYBASE:FBgn0028562
Locus tag
Dmel_CG17975
See related
AllianceGenome:FB:FBgn0028562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17975; Dmel\CG17975
Summary
Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in monosaccharide transmembrane transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A1 (solute carrier family 2 member 1); SLC2A4 (solute carrier family 2 member 4); and SLC2A5 (solute carrier family 2 member 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See sut2 in Genome Data Viewer
Location:
44A4-44A4; 2-58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8087396..8089297)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3974901..3976802)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 28 Neighboring gene saliva Neighboring gene sugar transporter 1 Neighboring gene sugar transporter 3 Neighboring gene sandman Neighboring gene univalents only

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila. Malita A, et al. Nat Metab, 2022 Nov. PMID 36344765, Free PMC Article
  2. A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila. Oh Y, et al. Nature, 2019 Oct. PMID 31645735, Free PMC Article
  3. Regulation of Notch signaling in the developing Drosophila eye by a T-box containing transcription factor, Dorsocross. Paul MS, et al. Genesis, 2018 Oct. PMID 30246928
  4. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article
  5. Identification of genes that influence gurken expression. Geng C, et al. Fly (Austin), 2007 Sep-Oct. PMID 18836312

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hexose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sugar transporter 2
Names
CG17975-PA
sut2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8087396..8089297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079993.3 → NP_524732.1  sugar transporter 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524732.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U622, Q9V361
    Related
    FBpp0087856
    Conserved Domains (2) summary
    cd06174
    Location:76 → 466
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:23 → 473
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U622 Q9U622

Gene LinkOut

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