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sut3 sugar transporter 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44268, updated on 4-Jan-2025

Summary

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Official Symbol
sut3provided by FlyBase
Official Full Name
sugar transporter 3provided by FlyBase
Primary source
FLYBASE:FBgn0028561
Locus tag
Dmel_CG17976
See related
AllianceGenome:FB:FBgn0028561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17976; Dmel\CG17976
Summary
Predicted to enable hexose transmembrane transporter activity. Involved in glucose homeostasis. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A1 (solute carrier family 2 member 1); SLC2A4 (solute carrier family 2 member 4); and SLC2A5 (solute carrier family 2 member 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See sut3 in Genome Data Viewer
Location:
44A4-44A4; 2-58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8089482..8091297)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3976987..3978802)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene saliva Neighboring gene sugar transporter 1 Neighboring gene sugar transporter 2 Neighboring gene sandman Neighboring gene univalents only Neighboring gene Transmembrane protein 63 Neighboring gene Cullin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of genes that influence gurken expression. Geng C, et al. Fly (Austin), 2007 Sep-Oct. PMID 18836312
  2. Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11. Ugrankar R, et al. Commun Biol, 2018. PMID 30271990, Free PMC Article
  3. The Drosophila blood-brain barrier: development and function of a glial endothelium. Limmer S, et al. Front Neurosci, 2014. PMID 25452710, Free PMC Article
  4. Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism. Ugrankar R, et al. Nat Commun, 2015 May 21. PMID 25994086, Free PMC Article
  5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hexose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sugar transporter 3
Names
CG17976-PA
CG17976-PB
sut3-PA
sut3-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8089482..8091297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079992.4 → NP_524731.1  sugar transporter 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KJP2, Q8T3V4
    Related
    FBpp0087857
    Conserved Domains (2) summary
    cd06174
    Location:66 → 451
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:28 → 466
    Sugar_tr; Sugar (and other) transporter

  2. NM_001273869.1 → NP_001260798.1  sugar transporter 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEF1, Q8T3V4
    Conserved Domains (1) summary
    cd06174
    Location:29 → 414
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEF1 A0A0B4KEF1
Q7KJP2 Q7KJP2
Q8T3V4 Q8T3V4

Gene LinkOut

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