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SPDYE5 speedy/RINGO cell cycle regulator family member E5 [ Homo sapiens (human) ]

Gene ID: 442590, updated on 23-Nov-2023

Summary

Official Symbol
SPDYE5provided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member E5provided by HGNC
Primary source
HGNC:HGNC:35464
See related
Ensembl:ENSG00000170092 AllianceGenome:HGNC:35464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.6), skin (RPKM 1.2) and 23 other tissues See more
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Genomic context

See SPDYE5 in Genome Data Viewer
Location:
7q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (75491630..75504316)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (76779599..76791648)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75121598..75133640)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901676 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75039418-75040358 Neighboring gene NSUN5 pseudogene 1 Neighboring gene POM121 transmembrane nucleoporin C Neighboring gene 7q11.23 proximal recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18294 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75083199-75083700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18295 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75115301-75115800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18297 Neighboring gene Sharpr-MPRA regulatory region 5953 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75160518-75161214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26178 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 3 Neighboring gene huntingtin interacting protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75224249-75225196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75232242-75233192 Neighboring gene MPRA-validated peak6604 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75240777-75241350 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75246639-75247140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75252505-75253458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75253459-75254412 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75260462-75260962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18298 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75268875-75269629 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75269630-75270383 Neighboring gene Sharpr-MPRA regulatory region 13243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75359065-75359566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18299

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General protein information

Preferred Names
speedy protein E5
Names
putative Speedy protein E5
speedy homolog E5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306141.4NP_001293070.1  speedy protein E5

    Status: VALIDATED

    Source sequence(s)
    AC211429
    Consensus CDS
    CCDS78241.1
    UniProtKB/Swiss-Prot
    A0A096LPK5, A6NIY4
    Related
    ENSP00000485398.1, ENST00000625065.4
    Conserved Domains (2) summary
    pfam12406
    Location:1390
    DUF3664; Surface protein
    pfam11357
    Location:194398
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    75491630..75504316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420408.1XP_047276364.1  speedy protein E5 isoform X2

    UniProtKB/Swiss-Prot
    A0A096LPK5, A6NIY4
  2. XM_047420407.1XP_047276363.1  speedy protein E5 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    76779599..76791648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099435.2: Suppressed sequence

    Description
    NM_001099435.2: This RefSeq was suppressed because currently there is insufficient support for the transcript and the protein, and the transcript may retain intronic sequence at its 5' end.