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FOXB2 forkhead box B2 [ Homo sapiens (human) ]

Gene ID: 442425, updated on 10-Dec-2024

Summary

Official Symbol
FOXB2provided by HGNC
Official Full Name
forkhead box B2provided by HGNC
Primary source
HGNC:HGNC:23315
See related
Ensembl:ENSG00000204612 MIM:619962; AllianceGenome:HGNC:23315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKH4; bA159H20.4
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See FOXB2 in Genome Data Viewer
Location:
9q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (77019655..77020953)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (89176172..89177470)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (79634571..79635869)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene prune homolog 2 with BCH domain Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:79398353-79399552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79402243-79402744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79402745-79403244 Neighboring gene prostate cancer associated 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:79502679-79503275 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:79512967-79513466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:79571299-79571800 Neighboring gene LYPLA2 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79626622-79627122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79627123-79627623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79629105-79629618 Neighboring gene uncharacterized LOC105376096 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:79652960-79653618 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:79653619-79654276 Neighboring gene MPRA-validated peak7269 silencer Neighboring gene ATP synthase membrane subunit f pseudogene 3 Neighboring gene replication factor C 5 pseudogene 1

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013735.1NP_001013757.1  forkhead box protein B2

    See identical proteins and their annotated locations for NP_001013757.1

    Status: VALIDATED

    Source sequence(s)
    AL353637
    Consensus CDS
    CCDS35045.1
    UniProtKB/Swiss-Prot
    Q5VYV0
    Related
    ENSP00000365898.1, ENST00000376708.1
    Conserved Domains (1) summary
    smart00339
    Location:13101
    FH; FORKHEAD

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    77019655..77020953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    89176172..89177470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)