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ZFAS1 ZNFX1 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 441951, updated on 25-Jan-2022

Summary

Official Symbol
ZFAS1provided by HGNC
Official Full Name
ZNFX1 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:33101
See related
Ensembl:ENSG00000177410 AllianceGenome:HGNC:33101
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSUP1; HSUP2; C20orf199; ZNFX1-AS1; NCRNA00275
Summary
This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2017]
Expression
Ubiquitous expression in ovary (RPKM 66.8), bone marrow (RPKM 54.6) and 24 other tissues See more
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Genomic context

See ZFAS1 in Genome Data Viewer
Location:
20q13.13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49278178..49289260)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47894715..47905797)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 27 Neighboring gene Sharpr-MPRA regulatory region 13855 Neighboring gene zinc finger NFX1-type containing 1 Neighboring gene small nucleolar RNA, C/D box 12C Neighboring gene small nucleolar RNA, C/D box 12B Neighboring gene small nucleolar RNA, C/D box 12 Neighboring gene uncharacterized LOC105372649 Neighboring gene potassium voltage-gated channel subfamily B member 1 Neighboring gene prostaglandin I2 synthase Neighboring gene uncharacterized LOC101927486

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • ZNFX1 antisense RNA 1 (non-protein coding)
  • ZNFX1 antisense gene protein 1

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003604.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AL049766
    Related
    ENST00000450535.5
  2. NR_003605.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at the 5' end and is shorter, compared to variant 1.
    Source sequence(s)
    AL049766
    Related
    ENST00000458653.5
  3. NR_003606.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two internal exons and is shorter, compared to variant 1.
    Source sequence(s)
    AL049766
    Related
    ENST00000417721.5
  4. NR_036658.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon and is shorter, compared to variant 1.
    Source sequence(s)
    AL049766
    Related
    ENST00000441722.5
  5. NR_036659.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal exon and uses an alternate 5' exon compared to variant 1.
    Source sequence(s)
    AL049766
    Related
    ENST00000326677.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    49278178..49289260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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