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BECN2 beclin 2 [ Homo sapiens (human) ]

Gene ID: 441925, updated on 25-Nov-2021

Summary

Official Symbol
BECN2provided by HGNC
Official Full Name
beclin 2provided by HGNC
Primary source
HGNC:HGNC:38606
See related
Ensembl:ENSG00000196289 MIM:615687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BECN1L1; BECN1P1
Orthologs
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Genomic context

See BECN2 in Genome Data Viewer
Location:
1q43
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (241957767..241959062)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (242121069..242122364)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene exonuclease 1 Neighboring gene ribosomal protein L23a pseudogene 20 Neighboring gene microtubule associated protein 1 light chain 3 gamma Neighboring gene cofilin 1 pseudogene 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor catabolic process IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
beclin-2
Names
Beclin-1-like protein 1
beclin-1 autophagy-related pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290693.1NP_001277622.1  beclin-2

    See identical proteins and their annotated locations for NP_001277622.1

    Status: VALIDATED

    Source sequence(s)
    HM031116
    Consensus CDS
    CCDS81433.1
    UniProtKB/Swiss-Prot
    A8MW95
    Related
    ENSP00000488361.1, ENST00000419583.2
    Conserved Domains (1) summary
    pfam04111
    Location:116428
    APG6; Autophagy protein Apg6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    241957767..241959062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_022940.1: Suppressed sequence

    Description
    NG_022940.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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