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OR4Q3 olfactory receptor family 4 subfamily Q member 3 [ Homo sapiens (human) ]

Gene ID: 441669, updated on 22-Sep-2022

Summary

Official Symbol
OR4Q3provided by HGNC
Official Full Name
olfactory receptor family 4 subfamily Q member 3provided by HGNC
Primary source
HGNC:HGNC:15426
See related
AllianceGenome:HGNC:15426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSA6; OR4Q4; OR14-3; C14orf13; c14_5008
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See OR4Q3 in Genome Data Viewer
Location:
14q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (19744740..19752334)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (13946887..13947828)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20215587..20216528)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 2 Neighboring gene olfactory receptor family 11 subfamily K member 2 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene olfactory receptor family 4 subfamily H member 12 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 4Q3
Names
olfactory receptor 4Q4
olfactory receptor OR14-3
olfactory receptor, family 4, subfamily Q, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405963.1NP_001392892.1  olfactory receptor 4Q3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL512310, KF455839
    UniProtKB/TrEMBL
    A0A2U3TZU4
  2. NM_172194.1NP_751944.1  olfactory receptor 4Q3 isoform 1

    See identical proteins and their annotated locations for NP_751944.1

    Status: PROVISIONAL

    Source sequence(s)
    AB065609
    UniProtKB/Swiss-Prot
    Q6IEX4, Q8NH05
    UniProtKB/TrEMBL
    A0A126GW32
    Conserved Domains (2) summary
    pfam00001
    Location:41288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35302
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    19744740..19752334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449618.1XP_024305386.1  olfactory receptor 4Q3 isoform X1

    Conserved Domains (1) summary
    cd15935
    Location:98355
    7tmA_OR4Q3-like; olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    13946887..13947828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)