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TSPAN11 tetraspanin 11 [ Homo sapiens (human) ]

Gene ID: 441631, updated on 10-Oct-2023

Summary

Official Symbol
TSPAN11provided by HGNC
Official Full Name
tetraspanin 11provided by HGNC
Primary source
HGNC:HGNC:30795
See related
Ensembl:ENSG00000110900 AllianceGenome:HGNC:30795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VSSW1971
Summary
Predicted to be involved in cell migration. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 4.2), gall bladder (RPKM 3.5) and 22 other tissues See more
Orthologs
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Genomic context

See TSPAN11 in Genome Data Viewer
Location:
12p11.21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (30926748..31016502)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (30801368..30891025)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31079682..31149534)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31027609-31028110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31062613-31063113 Neighboring gene uncharacterized LOC124902911 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31117766-31118266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31130578-31131412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31133507-31134008 Neighboring gene TSPAN11 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31134009-31134508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31140539-31141040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31141041-31141540 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31165500-31165701 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31181720-31181949 Neighboring gene DDX11 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31226445-31226976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31227509-31228038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31232984-31233540 Neighboring gene DEAD/H-box helicase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31256969-31257468

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
tetraspanin-11
Names
tspan-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080509.3NP_001073978.1  tetraspanin-11 isoform 1

    See identical proteins and their annotated locations for NP_001073978.1

    Status: VALIDATED

    Source sequence(s)
    AC008013, AC008150
    Consensus CDS
    CCDS31765.1
    UniProtKB/Swiss-Prot
    A1L157, A1L158, B2RUX6
    UniProtKB/TrEMBL
    B4DF63
    Related
    ENSP00000261177.9, ENST00000261177.10
    Conserved Domains (2) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16244
    Tetraspannin; Tetraspanin family
  2. NM_001370301.1NP_001357230.1  tetraspanin-11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008013, AC008150
    UniProtKB/TrEMBL
    B4DV40
    Conserved Domains (2) summary
    cd03155
    Location:102210
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:19234
    Tetraspannin; Tetraspanin family
  3. NM_001370302.1NP_001357231.1  tetraspanin-11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008013, AC008150
    Consensus CDS
    CCDS31765.1
    UniProtKB/Swiss-Prot
    A1L157, A1L158, B2RUX6
    UniProtKB/TrEMBL
    B4DF63
    Related
    ENSP00000437403.1, ENST00000546076.6
    Conserved Domains (2) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16244
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    30926748..31016502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520679.3XP_011518981.1  tetraspanin-11 isoform X1

    Conserved Domains (3) summary
    PHA03242
    Location:50118
    PHA03242; envelope glycoprotein M; Provisional
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16235
    Tetraspannin; Tetraspanin family

RNA

  1. XR_001748709.2 RNA Sequence

  2. XR_001748710.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    30801368..30891025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372080.1XP_054228055.1  tetraspanin-11 isoform X1

RNA

  1. XR_008488588.1 RNA Sequence

  2. XR_008488589.1 RNA Sequence