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CT45A5 cancer/testis antigen family 45 member A5 [ Homo sapiens (human) ]

Gene ID: 441521, updated on 12-Oct-2019

Summary

Official Symbol
CT45A5provided by HGNC
Official Full Name
cancer/testis antigen family 45 member A5provided by HGNC
Primary source
HGNC:HGNC:33270
See related
Ensembl:ENSG00000228836 MIM:300796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT455; CT45-3; CT45-4; CT45-6; CT45.5; CT45A3; CT45A4; CT45A6; CT45A7
Summary
This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Restricted expression toward testis (RPKM 9.7) See more

Genomic context

See CT45A5 in Genome Data Viewer
Location:
Xq26.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (135777130..135785514, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134945651..134963316, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MGAT2 pseudogene 2 Neighboring gene cancer/testis antigen family 45 member A3 Neighboring gene cancer/testis antigen family 45 member A6 Neighboring gene cancer/testis antigen family 45 member A2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC27005, MGC176412, MGC176603, MGC177976

Gene Ontology Provided by GOA

Process Evidence Code Pubs
snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cancer/testis antigen family 45 member A5
Names
Cancer/testis antigen 45-3
Cancer/testis antigen 45-4
Cancer/testis antigen 45-6
Cancer/testis antigen 45A3
Cancer/testis antigen 45A4
Cancer/testis antigen 45A6
Cancer/testis antigen 45A7
Cancer/testis antigen family 45 member A3
Cancer/testis antigen family 45 member A4
Cancer/testis antigen family 45 member A6
Cancer/testis antigen family 45 member A7
cancer/testis antigen 45-5
cancer/testis antigen 45A5
cancer/testis antigen CT45-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016551.3 RefSeqGene

    Range
    5005..13350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007551.4NP_001007552.2  cancer/testis antigen family 45 member A5

    See identical proteins and their annotated locations for NP_001007552.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC240441
    Consensus CDS
    CCDS35406.1
    UniProtKB/Swiss-Prot
    P0DMU7, P0DMU8, P0DMV0
    Conserved Domains (1) summary
    pfam15300
    Location:122183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  2. NM_001172288.2NP_001165759.2  cancer/testis antigen family 45 member A5

    See identical proteins and their annotated locations for NP_001165759.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC240441
    Consensus CDS
    CCDS35406.1
    UniProtKB/Swiss-Prot
    P0DMU7, P0DMU8, P0DMV0
    Related
    ENSP00000427342.2, ENST00000487941.6
    Conserved Domains (1) summary
    pfam15300
    Location:122183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    135777130..135785514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531341.3XP_011529643.1  cancer/testis antigen family 45 member A5 isoform X1

    See identical proteins and their annotated locations for XP_011529643.1

    UniProtKB/Swiss-Prot
    P0DMU7, P0DMU8, P0DMV0
    Related
    ENSP00000483658.1, ENST00000617203.1
    Conserved Domains (1) summary
    pfam15300
    Location:122183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
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