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CT45A3 cancer/testis antigen family 45 member A3 [ Homo sapiens (human) ]

Gene ID: 441519, updated on 25-Nov-2025
Official Symbol
CT45A3provided by HGNC
Official Full Name
cancer/testis antigen family 45 member A3provided by HGNC
Primary source
HGNC:HGNC:33268
See related
Ensembl:ENSG00000269096 MIM:300794; AllianceGenome:HGNC:33268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT45-3; CT45-4; CT45.3; CT45.4; CT45A4
Summary
Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward testis (RPKM 11.8) See more
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See CT45A3 in Genome Data Viewer
Location:
Xq26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135760044..135768191, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134103000..134111149, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134883488..134891634)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MGAT2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29986 Neighboring gene MGAT2 pseudogene 2 Neighboring gene cancer/testis antigen family 45 member A5 Neighboring gene cancer/testis antigen family 45 member A6

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen YT, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905330, Free PMC Article
  2. Cell Type-Specific Expression of Testis Elevated Genes Based on Transcriptomics and Antibody-Based Proteomics. Pineau C, et al. J Proteome Res, 2019 Dec 6. PMID 31429579
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks. Caron P, et al. Genes Dev, 2019 Jun 1. PMID 31048545, Free PMC Article
  5. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • FLJ25823, MGC183045, MGC184299

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cancer/testis antigen family 45 member A3
Names
cancer/testis antigen 45-3
cancer/testis antigen 45-4
cancer/testis antigen 45A3
cancer/testis antigen 45A4
cancer/testis antigen CT45-3
cancer/testis antigen family 45 member A4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017435.2 → NP_001017435.1  cancer/testis antigen family 45 member A3

    See identical proteins and their annotated locations for NP_001017435.1

    Status: VALIDATED

    Source sequence(s)
    AC240441
    Consensus CDS
    CCDS76030.1
    UniProtKB/Swiss-Prot
    B2RU20, B7ZMC9, D3DTG6, P0DMU6, Q8N7B7, Q8NHU0
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  2. NM_001370148.2 → NP_001357077.1  cancer/testis antigen family 45 member A3

    Status: VALIDATED

    Source sequence(s)
    AC240441, AI581344, AY743711, HY033723
    Consensus CDS
    CCDS76030.1
    UniProtKB/Swiss-Prot
    B2RU20, B7ZMC9, D3DTG6, P0DMU6, Q8N7B7, Q8NHU0
    Related
    ENSP00000471571.2, ENST00000598716.3
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  3. NM_001370149.1 → NP_001357078.1  cancer/testis antigen family 45 member A3

    Status: VALIDATED

    Source sequence(s)
    AC240441
    Consensus CDS
    CCDS76030.1
    UniProtKB/Swiss-Prot
    B2RU20, B7ZMC9, D3DTG6, P0DMU6, Q8N7B7, Q8NHU0
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    135760044..135768191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    134103000..134111149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NHU0.1 GenPept UniProtKB/Swiss-Prot:Q8NHU0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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