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LRRC24 leucine rich repeat containing 24 [ Homo sapiens (human) ]

Gene ID: 441381, updated on 13-May-2022

Summary

Official Symbol
LRRC24provided by HGNC
Official Full Name
leucine rich repeat containing 24provided by HGNC
Primary source
HGNC:HGNC:28947
See related
Ensembl:ENSG00000254402 AllianceGenome:HGNC:28947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC14OS
Summary
Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 10.0), brain (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

See LRRC24 in Genome Data Viewer
Location:
8q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144522388..144527033, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145692574..145697219, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145747772..145752417, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RecQ like helicase 4 Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 11949 Neighboring gene leucine rich repeat containing 14 Neighboring gene chromosome 8 open reading frame 82 Neighboring gene Rho GTPase activating protein 39 Neighboring gene Sharpr-MPRA regulatory region 12231

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of leucine rich repeat containing 24 (LRRC24) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111484

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024678.4NP_001019849.2  leucine-rich repeat-containing protein 24 precursor

    See identical proteins and their annotated locations for NP_001019849.2

    Status: VALIDATED

    Source sequence(s)
    AC084125, BC111067
    Consensus CDS
    CCDS34969.1
    UniProtKB/Swiss-Prot
    Q50LG9
    Related
    ENSP00000434849.1, ENST00000529415.7
    Conserved Domains (6) summary
    smart00082
    Location:204257
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:266362
    IG_like; Immunoglobulin like
    cd00116
    Location:49158
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5375
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76134
    LRR_8; Leucine rich repeat
    cl11960
    Location:259364
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144522388..144527033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145692574..145697219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)