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CALHM6 calcium homeostasis modulator family member 6 [ Homo sapiens (human) ]

Gene ID: 441168, updated on 11-Jun-2021

Summary

Official Symbol
CALHM6provided by HGNC
Official Full Name
calcium homeostasis modulator family member 6provided by HGNC
Primary source
HGNC:HGNC:33391
See related
Ensembl:ENSG00000188820 MIM:617305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INAM; FAM26F; C6orf187; dJ93H18.5
Expression
Biased expression in spleen (RPKM 28.1), appendix (RPKM 12.4) and 12 other tissues See more
Orthologs
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Genomic context

See CALHM6 in Genome Data Viewer
Location:
6q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (116461375..116463782)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116782538..116784934)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromobox 3 pseudogene 9 Neighboring gene keratin 18 pseudogene 22 Neighboring gene trafficking protein particle complex subunit 3L Neighboring gene calcium homeostasis modulator family member 5 Neighboring gene calcium homeostasis modulator family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of family with sequence similarity 26, member F (FAM26F) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calcium homeostasis modulator protein 6
Names
IFN regulatory factor 3-dependent NK-activating molecule
family with sequence similarity 26 member F
protein FAM26F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010919.3NP_001010919.1  calcium homeostasis modulator protein 6 isoform 1

    See identical proteins and their annotated locations for NP_001010919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF086130, AV734646, BM704529, DN997293
    Consensus CDS
    CCDS34519.1
    UniProtKB/Swiss-Prot
    Q5R3K3
    Related
    ENSP00000357594.1, ENST00000368605.3
    Conserved Domains (1) summary
    pfam14798
    Location:2246
    Ca_hom_mod; Calcium homeostasis modulator
  2. NM_001276460.2NP_001263389.1  calcium homeostasis modulator protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001263389.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, which results in an alternate upstream start codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF086130, AV734646
    Consensus CDS
    CCDS64506.1
    UniProtKB/Swiss-Prot
    Q5R3K3
    Related
    ENSP00000357595.3, ENST00000368606.7
    Conserved Domains (1) summary
    pfam14798
    Location:2074
    Ca_hom_mod; Calcium homeostasis modulator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    116461375..116463782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535845.3XP_011534147.1  calcium homeostasis modulator protein 6 isoform X1

    Conserved Domains (1) summary
    pfam14798
    Location:4268
    Ca_hom_mod; Calcium homeostasis modulator
  2. XM_005266999.4XP_005267056.1  calcium homeostasis modulator protein 6 isoform X2

    See identical proteins and their annotated locations for XP_005267056.1

    UniProtKB/Swiss-Prot
    Q5R3K3
    Conserved Domains (1) summary
    pfam14798
    Location:2246
    Ca_hom_mod; Calcium homeostasis modulator
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